Mouse Strain information
APB ID 67
Added 06/02/2006
Last Edited 10/05/2014
Strain name: STOCK Ltn1lister/AnuApb
Nickname: Listerin, Senseless
Strain designation name: STOCK Ltn1lister/AnuApb
Genetics
Strain Types Mutant strain
Genetic Details Chemically induced : ENU
Mode of Inheritance Recessive
1.  Affected Gene Name: listerin E3 ubiquitin protein ligase 1  
Chromosome 16
Affected Gene Symbol Ltn1
Protein expression of altered gene: Normal
Genetic alteration of gene: ENU induced mutation. The resulting transcript lacks exon 11 producing a mutant protein that lacks the 14 amino acids (708 -721) encoded by this exon.
Location on chromosome (bp): 87376896-87432851 bp, - strand (From NCBI annotation of NCBI Build 37)
MGI Gene Accession ID

Please also use this link to determine if other mutants have been registered with MGI (Mouse Genome Informatics)

MGI:1926163
Synonyms Listerin, Rnf160, Zfp294
Allele Name listerin E3 ubiquitin protein ligase 1; lister
Allele Symbol Ltn1lister
MGI Allele Accession ID MGI:3838105
Ensembl Gene ID: ENSMUSG00000052299
Transcript ID: ENSMUST00000039449
Transcript name: Rnf160-201
bp change: T to A
Intron number: 11
Genomic position: 87415397
Sequence:
87415427GGAGTTCTCTTCTTCAGGTCATTGAAAAGgTattttagccccctctcccctttccctttcttgenomic (reverse strand)
    Exons
Version: NCBI m37, Ensembl build 57
Mutant Construction Technique None
Phenotype
Phenotype Homozygous State Late onset spastic paralysis & appear to have sensory defects, progresses to seizures and death
Original Genetic Background C57BL/6JSfdAnu
Genetic Background Currently Maintained C57BL/6JSfdAnu x NOD
Strain identification
How is this strain characterised? Genotyping
PCR protocols Senseless (amplifluor)
Fertility and Strain maintenance
Fertility and Strain maintenance
Relevant bibliographic / database references
Strain Specific References
Other Related References
General information
Associated IP rights? No
Does it Model a Human Condition? Unknown
Applicable Research Areas Neurobiology
Keywords
  • paralysis
  • seizures
  • ataxia
  • ENU
Is the strain available in any form to other researchers Yes
APB stock stored as: Cryopreserved sperm (from 14 mice)

APB stock genotyped verified by: The APF
Are live mice available? No
MTA needs to be signed? Yes


   

 


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