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Mouse Strain information

APB ID

Added

06/02/2006

Last Edited

10/05/2014

Strain nomenclature:

STOCK Ltn1lister/AnuApb

Nickname:

Listerin, Senseless

Strain designation name:

STOCK Ltn1lister/AnuApb

Genetics

Strain Types

Mutant strain

Genetic Details

Chemically induced : ENU

Mode of Inheritance

Recessive

1. Affected Gene Name: listerin E3 ubiquitin protein ligase 1

Chromosome

Affected Gene Symbol

Ltn1

Protein expression of altered gene:

Normal

Genetic alteration of gene:

ENU induced mutation. The resulting transcript lacks exon 11 producing a mutant protein that lacks the 14 amino acids (708 -721) encoded by this exon.

Location on chromosome (bp):

87376896-87432851 bp, - strand (From NCBI annotation of NCBI Build 37)

MGI Gene Accession ID

Please also use this link to determine if other mutants have been registered with MGI (Mouse Genome Informatics)

MGI:1926163

Synonyms

Listerin, Rnf160, Zfp294

Allele Name

listerin E3 ubiquitin protein ligase 1; lister

Allele Symbol

Ltn1lister

MGI Allele Accession ID

MGI:3838105

Ensembl Gene ID:

ENSMUSG00000052299

Transcript ID:

ENSMUST00000039449

Transcript name:

Rnf160-201

bp change:

T to A

Intron number:

Genomic position:

87415397

Sequence:
87415427	GGAGTTCTCTTCTTCAGGTCATTGAAAAGgTattttagccccctctcccctttccctttctt	genomic (reverse strand)
	Exons

Version:

NCBI m37, Ensembl build 57

Mutant Construction Technique

None

Phenotype

Phenotype Homozygous State

Late onset spastic paralysis & appear to have sensory defects, progresses to seizures and death

Original Genetic Background

C57BL/6JSfdAnu

Genetic Background Currently Maintained

C57BL/6JSfdAnu x NOD

Strain identification

How is this strain characterised?

Genotyping

PCR protocols

Senseless (amplifluor)

Fertility and Strain maintenance

Fertility and Strain maintenance

Relevant bibliographic / database references

Strain Specific References

Other Related References

General information

Associated IP rights?

Does it Model a Human Condition?

Unknown

Applicable Research Areas

Neurobiology

Keywords

paralysis
seizures
ataxia
ENU

Is the strain available in any form to other researchers

Yes

APB stock stored as:

Cryopreserved sperm (from 14 mice)

APB stock genotyped verified by:

The APF

Are live mice available?

MTA needs to be signed?

Yes