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Mouse Strain information

APB ID

5174

Added

08/07/2010

Last Edited

19/05/2014

Strain nomenclature:

C57BL/6JAnu-Cd4maat/AnuApb

Nickname:

Nehmet ; Maat ; ENU15China:011a

Strain designation name:

C57BL/6JAnu-Cd4maat/AnuApb

Genetics

Strain Types

Mutant strain

Genetic Details

Chemically induced : ENU

Mode of Inheritance

Recessive

1. Affected Gene Name: CD4 antigen

Chromosome

Affected Gene Symbol

Cd4

Protein expression of altered gene:

Unknown

Genetic alteration of gene:

ENU-induced mutation

Location on chromosome (bp):

124814710-124838239 bp, - strand (From VEGA annotation of NCBI Build 37)

MGI Gene Accession ID

Please also use this link to determine if other mutants have been registered with MGI (Mouse Genome Informatics)

MGI:88335

Synonyms

L3T4, Ly-4

Allele Name

Maat

Allele Symbol

Cd4Maat

MGI Allele Accession ID

MGI:4819382

Ensembl Gene ID:

ENSMUSG00000023274

Transcript ID:

ENSMUST00000024044

Transcript name:

Cd4-001

bp change:

T to A

Intron number:

Genomic position:

124816702

Sequence:
124816732	gaggactgggaccctcacgactactctcctTgtccctgggcagCGCCAGGCAGCACGAATGT	genomic (reverse strand)
	Exons

Version:

NCBI m37, Ensembl build 57

Mutant Construction Technique

None

Phenotype

Phenotype Homozygous State

Low CD4 expression and CD4+ T cell numbers. High CD8+ T cell numbers

Original Genetic Background

C57BL/6JAnu

Genetic Background Currently Maintained

C57BL/6JAnu

Strain identification

How is this strain characterised?

Phenotyping
Genotyping

Fertility and Strain maintenance

Fertility and Strain maintenance

Relevant bibliographic / database references

General information

Associated IP rights?

Unknown

Does it Model a Human Condition?

Unknown

Applicable Research Areas

Immunology and inflammation

Keywords

T cell
CD4
CD8
selection
ENU
China

Is the strain available in any form to other researchers

Yes

APB stock stored as:

Cryopreserved sperm (from 6 mice)

APB stock genotyped verified by:

Unverified

Are live mice available?

MTA needs to be signed?

Yes