Mouse Strain information
APB ID 5037
Added 22/02/2010
Last Edited 10/05/2014
Strain nomenclature: C57BL/6JAnu-Atp11cambr/AnuApb
Nickname: ENU11B6:221d ; ambrosius
Strain designation name: C57BL/6JAnu-Atp11cambr/AnuApb
Genetics
Strain Types Mutant strain
Genetic Details Chemically induced : ENU
Mode of Inheritance X-linked
1.  Affected Gene Name: ATPase, class VI, type 11C  
Chromosome X
Affected Gene Symbol Atp11c
Genetic alteration of gene: ENU-induced mutation. Mutation lies in the first base of intron 27 and is a g to a substitution. This results in a STOP being made as part of the last 2 bases of exon 27 (TG (exon) + A (intron)).
Location on chromosome (bp): 57476467-57845873 bp, - strand (From VEGA annotation of NCBI Build 37)
MGI Gene Accession ID

Please also use this link to determine if other mutants have been registered with MGI (Mouse Genome Informatics)

 MGI:1859661
Synonyms Ig
Allele Name ambrosius
Allele Symbol Atp11cambr
MGI Allele Accession ID MGI:4456247
Allele synonyms: Atp11cm1Anu
Ensembl Gene ID: ENSMUSG00000062949
Transcript ID: ENSMUST00000154051
Transcript name: Atp11c-001
bp change: G to A
Intron number: 27
Genomic position: 57491646
Sequence:
57491676TTTCTCATTCTTCTGGGGAGGAATTATTTGGtaagcagctgtacctgtgtgagcaatattaagenomic (reverse strand)
    Exons
Version: NCBI m37, Ensembl build 57
Mutant Construction Technique None
Phenotype
Phenotype Homozygous State No B cells. Defective ATP11C resulted in a lower rate of phosphatidylserine translocation in pro-B cells and much lower pre-B cell and B cell numbers despite expression of pre-rearranged immunoglobulin transgenes or enforced expression of the prosurvival protein Bcl-2 to prevent apoptosis and abolished pre-B cell population expansion in response to a transgene encoding interleukin 7.
Original Genetic Background C57BL/6JAnu
Genetic Background Currently Maintained C57BL/6JAnu
Strain identification
How is this strain characterised? Phenotyping
Fertility and Strain maintenance
Fertility and Strain maintenance
Relevant bibliographic / database references
Strain Specific References
Other Related References
General information
Associated IP rights? Unknown
Does it Model a Human Condition? Unknown
Applicable Research Areas Immunology and inflammation
Keywords
  • ENU
  • B cell
  • NIH
  • Wellcome Trust
Is the strain available in any form to other researchers Yes
APB stock stored as: Cryopreserved sperm (from 9 mice)

APB stock genotyped verified by: Unverified
Are live mice available? Unknown
MTA needs to be signed? Yes


     

 


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