Mouse Strain information
APB ID 282
Added 02/05/2006
Last Edited 11/05/2014
Strain name: 129/Sv-Ifngrtm1Agt/Apb
Genetics
Strain Types Mutant strain
Recombinant inbred
Genetic Details Targeted knockout
Mode of Inheritance Recessive
1.  Affected Gene Name: interferon gamma receptor 1  
Chromosome 10
Affected Gene Symbol Ifngr1
Protein expression of altered gene: Unknown
Genetic alteration of gene: Insertion of a neomycin cassette into exon V, which encodes an extracellular membrane-proximal portion of the receptor.
Location on chromosome (bp): 19518118-19537502 bp, + strand (From NCBI annotation of NCBI Build 34)
MGI Gene Accession ID

Please also use this link to determine if other mutants have been registered with MGI (Mouse Genome Informatics)

MGI:107655
Synonyms CD119, Ifgr, IFN-gamma R, Ifngr, INF-g receptor, Nktar
Allele Name targeted mutation 1, Michel Aguet
Allele Symbol Ifngr1tm1Agt
MGI Allele Accession ID MGI:1857286
Allele synonyms: IFn type II receptor, IFN-gamma R-, IFN-gamma R0, IFN-gamma-R KO, IFN-gammaR KO, IFN-gammaR-, IFN-gammaR0, IFN-gammaR1-, IFN-gammaRalpha_, IFNgammaR KO, IFNgR KO, Ifngr-, Ifngr1-
Mutant Construction Technique None
Phenotype
Phenotype Homozygous State abnormal immunoglobulin level: levels of IgG2a and IgG2b neutralizing antibodies are reduced relative to controls after secondary infection with Ectromelia virus increased susceptibility to viral infection: slightly more susceptible to MCMV viral infection than controls increased susceptibility to Ectromelia virus 100% mortality by day 6-12 after primary infection infection elevated virus titers in all organs tested after primary infection but much improved after secondary infections survive secondary infections
Original Genetic Background 129
Genetic Background Currently Maintained 129
Strain identification
How is this strain characterised? Genotyping
Fertility and Strain maintenance
Fertility and Strain maintenance
Relevant bibliographic / database references
Strain Specific References
Other Related References
General information
Associated IP rights? No
Does it Model a Human Condition? Unknown
Applicable Research Areas Cell biology
Immunology and inflammation
Haematology
Keywords
  • infection
  • interleukin
  • splenocyte
Additional Information Permission for access maybe required from Jax. Control strain also cryopreserved. ASD114, APB ID#4779
Is the strain available in any form to other researchers Yes
APB stock stored as: Cryopreserved sperm (from 10 mice)

APB stock genotyped verified by: Unverified
Are live mice available? No
MTA needs to be signed? Yes


   

 


Build: 2020.10.23 Non-profit supported by the Australian government  |  © Copyright 2020 Australian Phenomics Facility Last updated: 25/11/2020