Mouse Strain information
APB ID 93
Added 06/02/2006
Last Edited 11/05/2014
Strain name: C57BL/6JSfdAnu-Nfkb2xdr/AnuApb
Nickname: Xander
Strain designation name: C57BL/6JSfdAnu-Nfkb2xdr/AnuApb
Genetics
Strain Types Mutant strain
Coisogenic
Genetic Details Chemically induced : ENU
Mode of Inheritance Recessive
1.  Affected Gene Name: nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100  
Chromosome 19
Affected Gene Symbol NFkb2
Protein expression of altered gene: Nil
Genetic alteration of gene: ENU induced mutation
Location on chromosome (bp): 46380108-46386580 bp, + strand (From NCBI annotation of NCBI Build 37)
MGI Gene Accession ID

Please also use this link to determine if other mutants have been registered with MGI (Mouse Genome Informatics)

MGI:1099800
Synonyms lyt, NF-kappaB2, p49, p49/p100, p50B, p52
Allele Name xander
Allele Symbol Nfkb2xdr
MGI Allele Accession ID MGI:2667230
Ensembl Gene ID: ENSMUSG00000025225
Transcript ID: ENSMUST00000073116
Transcript name: Nfkb2-201
bp change: T to A
Intron number: 6
Genomic position: 46381842
Sequence:
46381812tcatggtcaaagaggacaaagcctcctcctTgtcctctccagATTTAATAATCTGGGTGTCCgenomic (forward strand)
    Exons
Version: NCBI m37, Ensembl build 55
Mutant Construction Technique None
Phenotype
Phenotype Homozygous State Normal Thy1.2⁺ cells Reduced B220⁺ cells Decrease numbers of peripheral B cells, normal numbers of BM B cells Normal T cell numbers Decreased mature B2 cells in spleen Seven fold decrease in B1 cells in peritoneal cavity Small peripheral lymph nodes Disturbed splenic microarchitecture Lack of follicular dendritic cell clusters in spleen. Intrinsic to B cells
Original Genetic Background C57BL/6JSfdAnu
Genetic Background Currently Maintained C57BL/6JSfdAnu
Strain identification
How is this strain characterised? Genotyping
PCR protocols Xander (Amplifluor)
Xander (Xdr)
Fertility and Strain maintenance
Fertility and Strain maintenance
Relevant bibliographic / database references
Strain Specific References
Other Related References
General information
Associated IP rights? No
Does it Model a Human Condition? Unknown
Applicable Research Areas Immunology and inflammation
Keywords
  • B cell
  • follicular dendritic cell
  • spleen
  • lymphocyte
Is the strain available in any form to other researchers Yes
APB stock stored as: Cryopreserved sperm (from 2 mice)

APB stock genotyped verified by: Unverified
Are live mice available? Unknown
MTA needs to be signed? Yes


   

 


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