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Mouse Strain information

APB ID

Added

06/02/2006

Last Edited

10/05/2014

Strain nomenclature:

C57BL/6JSfdAnu-Muc2wnn/AnuApb

Nickname:

Winnie

Strain designation name:

C57BL/6JSfdAnu-Muc2wnn/AnuApb

Genetics

Strain Types

Mutant strain

Genetic Details

Chemically induced : ENU

Mode of Inheritance

Recessive

1. Affected Gene Name: mucin 2

Chromosome

Affected Gene Symbol

Muc2

Protein expression of altered gene:

Nil

Genetic alteration of gene:

ENU induced mutation

MGI Gene Accession ID

Please also use this link to determine if other mutants have been registered with MGI (Mouse Genome Informatics)

MGI:1339364

Allele Name

Winnie

Allele Symbol

Muc2wnn

MGI Allele Accession ID

MGI:3614806

Ensembl Gene ID:

ENSMUSG00000025515

Transcript ID:

ENSMUST00000026590

Transcript name:

Muc2-202

bp change:

G to A at position 2968 on cDNA

Exon number:

Exon ID:

ENSMUSE00000467940

cDNA position:

2968

Amino acid change:

Cysteine to Tyrosine at position 988

Sequence:
2938	AGCTGGACCCCTCTTACAAGGGCACTGTATGTGGTCTGTGTGGGAACTTTGATGACCAGAC	cDNA (forward strand)
978	K--L--D--P--S--Y--K--G--T--V--C--G--L--C--G--N--F--D--D--Q--T	protein

Version:

NCBI m37, Ensembl build 57

Mutant Construction Technique

None

Phenotype

Phenotype Homozygous State

Diarrhoea, soft feces at weaning, some develop rectal prolapse. GIT does not appear inflamed, goblet cell hyperplasia and developmental or functional deficiency - malabsorption syndrome

Original Genetic Background

C57BL/6JSfdAnu

Genetic Background Currently Maintained

C57BL/6JSfdAnu

Coat Colour

Black

Strain identification

Fertility and Strain maintenance

Fertility and Strain maintenance

Relevant bibliographic / database references

General information

Associated IP rights?

Does it Model a Human Condition?

Unknown

Applicable Research Areas

Metabolism

Keywords

diarrhoea
malabsorption
goblet cell
ENU

Is the strain available in any form to other researchers

Yes

APB stock stored as:

Cryopreserved sperm (from 7 mice)

APB stock genotyped verified by:

The APF

Are live mice available?

MTA needs to be signed?

Yes