Mouse Strain information
Added 06/02/2006
Last Edited 10/05/2014
Strain name: C57BL/6JSfdAnu-Jak3wil/AnuApb
Nickname: Willow
Strain designation name: C57BL/6JSfdAnu-Jak3wil/AnuApb
Strain Types Mutant strain
Genetic Details Chemically induced : ENU
Mode of Inheritance Recessive
1.  Affected Gene Name: Janus kinase 3  
Chromosome 8
Affected Gene Symbol Jak3
Protein expression of altered gene: Nil
Genetic alteration of gene: ENU induced mutation
Location on chromosome (bp): 74200195-74214474 bp, + strand (From VEGA annotation of NCBI Build 37)
MGI Gene Accession ID

Please also use this link to determine if other mutants have been registered with MGI (Mouse Genome Informatics)

Allele Name willow
Allele Symbol Jak3wil
MGI Allele Accession ID MGI:3611885
Ensembl Gene ID: ENSMUSG00000031805
Transcript ID: ENSMUST00000051995
Transcript name: Jak3-001
bp change: G to T at position 2771 on cDNA
Exon number: 18
Exon ID: ENSMUSE00000213233
cDNA position: 2771
Amino acid change: Glycine to Valine at position 825
Version: NCBI m37, Ensembl build 67
Mutant Construction Technique None
Phenotype Homozygous State Lymphopenia due to reduction of both Thy1.2⁺ and B220⁺ cells Reduced numbers of CD8⁺ cells B cell block in transition from pro-pre B cells; Develop autoimmune inflammatory bowel disease associated with diarrhoea and prolapse. Homozygotes have reduced life span. ? SCID phenotype.
Original Genetic Background C57BL/6JSfdAnu
Genetic Background Currently Maintained C57BL/6JSfdAnu
Strain identification
How is this strain characterised? Genotyping
PCR protocols Willow
Fertility and Strain maintenance
Fertility and Strain maintenance
Relevant bibliographic / database references
General information
Associated IP rights? No
Does it Model a Human Condition? Unknown
Applicable Research Areas Immunology and inflammation
  • B cell
  • T cell
  • maturation
  • lymphopenia
  • ENU
Is the strain available in any form to other researchers Yes
APB stock stored as: Cryopreserved sperm (from 11 mice)

APB stock genotyped verified by: The APF
Are live mice available? No
MTA needs to be signed? Yes



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