Mouse Strain information
Added 06/02/2006
Last Edited 10/05/2014
Strain name: C57BL/6JSfdAnu-Leprbrta/AnuApb
Nickname: Alberta
Strain designation name: C57BL/6JSfdAnu-Leprbrta/AnuApb
Strain Types Mutant strain
Genetic Details Chemically induced : ENU
Mode of Inheritance Recessive
1.  Affected Gene Name: leptin receptor  
Chromosome 4
Affected Gene Symbol LepR
Protein expression of altered gene: Unknown
Genetic alteration of gene: ENU induced mutation. The splice donor site at the exon 10/intron 10-11 boundary, following the triplet coding for valine at amino acid position 532, has been mutated to CGTAGGT/CACG
Location on chromosome (bp): 101390009-101487957 bp, + strand (From VEGA annotation of NCBI Build 37)
MGI Gene Accession ID

Please also use this link to determine if other mutants have been registered with MGI (Mouse Genome Informatics)

Synonyms LEPROT, leptin receptor gene-related protein, OB-RGRP, obese-like, obl, Obr
Allele Name alberta
Allele Symbol Leprbrta
MGI Allele Accession ID MGI:3847119
Ensembl Gene ID: ENSMUSG00000057722
Transcript ID: ENSMUST00000037552
Transcript name: Lepr-001
bp change: T to C
Intron number: 10
Genomic position: 101768248
101768218ACCAACGTGTGTCCTTCCTGACTCCGTAGgTacgtcagactatattatgtattttccttatagenomic (forward strand)
Version: NCBI m38, Ensembl build 75
Mutant Construction Technique None
Phenotype Homozygous State Homozygotes develop severe obesity evident by 4-8weeks. 50% develop diabetes by 6 weeks of age. Homozygotes don't breed
Original Genetic Background C57BL/6JSfdAnu
Genetic Background Currently Maintained C57BL/6JSfdAnu
Coat Colour Black
Eye Colour Black
Strain identification
How is this strain characterised? Genotyping
Fertility and Strain maintenance
Fertility and Strain maintenance
Relevant bibliographic / database references
General information
Associated IP rights? No
Does it Model a Human Condition? Yes
Applicable Research Areas Metabolism
  • obesity
  • leptin
  • diet
  • ENU
Is the strain available in any form to other researchers Yes
APB stock stored as: Cryopreserved sperm (from 9 mice)

APB stock genotyped verified by: Unverified
Are live mice available? No
MTA needs to be signed? Yes



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