Mouse Strain information
APB ID 632
Added 25/04/2007
Last Edited 13/06/2011
Strain name: B6;129-Tlr3tm1Flv Eif2ak2tm1Cwe
Nickname: T3DKO
Strain designation name: B6;129-Tlr3tm1Flv Eif2ak2tm1Cwe
Genetics
Strain Types Mutant strain
Genetic Details Targeted knockout
Mode of Inheritance Dominant
1.  Affected Gene Name: toll-like receptor 3  
Chromosome 8
Affected Gene Symbol Tlr3
Protein expression of altered gene: Unknown
Genetic alteration of gene: The gene was disrupted by replacement of exon 1 with a floxed neo cassette via homologous recombination. Northern blot analysis detected a truncated transcript in mutant animals. The mutant transcript does not encode a functional protein.
Location on chromosome (bp): 46481019-46495893 bp, - strand (From NCBI annotation of NCBI Build 37)
MGI Gene Accession ID

Please also use this link to determine if other mutants have been registered with MGI (Mouse Genome Informatics)

MGI:2156367
Allele Name targeted mutation 1, Richard A Flavell
Allele Symbol Tlr3tm1Flv
MGI Allele Accession ID MGI:2653138
Allele synonyms: TLR-, Tlr3-
Mutant Construction Technique None
Phenotype
Phenotype Homozygous State Comparable spleen and bone marrow cell populations in tlr3(-/)-, pkr(-/-), and tlr3(-/-)pkr(-/-) mice to wild-type controls. Splenomegaly developing between 8 and 10 weeks of age was observed in tlr3(-/-) and tlr3(-/-)pkr(-/-) mice but not in wild-type or pkr(-/-) mice. These data also suggest that PKR may have a role in preventing progression from splenomegaly to lymphadenopathy in these mice.
Original Genetic Background 129
Genetic Background Currently Maintained C57BL/6 x 129
Strain identification
How is this strain characterised? Genotyping
Fertility and Strain maintenance
Fertility and Strain maintenance
Relevant bibliographic / database references
Strain Specific References
Other Related References
General information
Associated IP rights? No
Does it Model a Human Condition? Unknown
Applicable Research Areas Haematology
Apoptosis
Keywords
  • splenomegaly
  • lymphadenopathy
  • lymphocyte
  • lymph node
Is the strain available in any form to other researchers Yes
APB stock stored as:

APB stock genotyped verified by: The depositor
Are live mice available? Unknown
MTA needs to be signed? Yes


   

 


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