Mouse Strain information
APB ID 6
Added 28/11/2005
Last Edited 10/05/2014
Strain name: C57BL/6JSfdAnu-Stat1fae/AnuApb
Nickname: Face
Strain designation name: C57BL/6JSfdAnu-Stat1fae/AnuApb
Genetics
Strain Types Mutant strain
Coisogenic
Genetic Details Chemically induced : ENU
Mode of Inheritance Recessive
1.  Affected Gene Name: signal transducer and activator of transcription 1  
Chromosome 1
Affected Gene Symbol Stat1
Protein expression of altered gene: Unknown
Genetic alteration of gene: ENU induced mutation
Location on chromosome (bp): 52176282-52218704 bp, + strand (From Ensembl annotation of NCBI Build 37)
MGI Gene Accession ID

Please also use this link to determine if other mutants have been registered with MGI (Mouse Genome Informatics)

MGI:103063
Synonyms STAT-1
Allele Name face
Allele Symbol Stat1fae
MGI Allele Accession ID MGI:3611892
Ensembl Gene ID: ENSMUSG00000026104
Transcript ID: ENSMUST00000070968
Transcript name: Stat1-201
bp change: T to A at position 2329 on cDNA
Exon number: 22
Exon ID: ENSMUSE00000630003
cDNA position: 2329
Amino acid change: Methionine to Lysine at position 660
Sequence:
2299TCCCAGATATTATTCGCAACTACAAAGTCATGGCTGCCGAGAACATACCAGAGAATCCCCTcDNA (forward strand)
650-F--P--D--I--I--R--N--Y--K--V--M--A--A--E--N--I--P--E--N--P--protein
Version: NCBI m37, Ensembl build 59
Mutant Construction Technique None
Phenotype
Phenotype Homozygous State Diminished Th1 antibody formation upon immunization with heat-killed Bordetella pertussis bacilli. Increase proportion of CD44hi activated/memory T cells in a subset of animals and increased IgE.
Original Genetic Background C57BL/6JSfdAnu
Genetic Background Currently Maintained C57BL/6JSfdAnu
Coat Colour Black
Strain Images
Serum IgG1 or IgG2c (IgG2a of the b allotype denoted here as “IgG2ab”) antibody titres in individual C57BL/6 face homozygous mice and wild-type controls, 14 days after immunization with an alum precipitated mixture of killed B pertussis bacteria (Bpert) and chicken gammaglobulin (CGG).
Serum IgG1 or IgG2c (IgG2a of the b allotype denoted here as “IgG2ab”) antibody titres in individual C57BL/6 face homozygous mice and wild-type controls, 14 days after immunization with an alum precipitated mixture of killed B pertussis bacteria (Bpert) and chicken gammaglobulin (CGG).
Strain identification
How is this strain characterised? Genotyping
Fertility and Strain maintenance
Fertility and Strain maintenance
Relevant bibliographic / database references
General information
Associated IP rights? No
Does it Model a Human Condition? Unknown
Applicable Research Areas Immunology and inflammation
Keywords
  • T cell
  • hypergammaglobulinaemia
  • B cell
  • ENU
  • Wellcome Trust
Additional Information Discovered by Wellcome Trust immunization and flow cytometry screen by Lauren Wilson, Adele Yates, Edyta Kucharska & Carola Vinuesa (JCSMR, ANU). Mutation mapped and identified by Belinda Whittle and Adele Yates. Project guided by Prof Chris Goodnow and Dr Ed Bertram.
Is the strain available in any form to other researchers Yes
APB stock stored as: Cryopreserved sperm (from 14 mice)

APB stock genotyped verified by: The APF
Are live mice available? No
MTA needs to be signed? Yes


   

 


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