Mouse Strain information
APB ID 4991
Added 28/01/2010
Last Edited 19/05/2014
Strain name: C57BL/6-Ticam1Lps2/BtlrAnuApb
Nickname: Lps2
Strain designation name: C57BL/6-Ticam1Lps2/BtlrAnuApb
Genetics
Genetic Details Chemically induced : ENU
Mode of Inheritance Recessive
1.  Affected Gene Name: toll-like receptor adaptor molecule 1  
Chromosome 17
Affected Gene Symbol Ticam1
Genetic alteration of gene: ENU mutagenesis induced the deletion of a single guanine within codon 708, resulting in a frameshift mutation. The mutation was predicted to replace 24 C-terminal residues with 11 unrelated residues. The mutation was initially detected by screening macrophages for their competence to respond to LPS.
Location on chromosome (bp): 56408742-56416209 bp, - strand (From VEGA annotation of NCBI Build 37)
MGI Gene Accession ID

Please also use this link to determine if other mutants have been registered with MGI (Mouse Genome Informatics)

MGI:2147032
Synonyms TICAM-1, Trif
Allele Name toll-like receptor adaptor molecule 1; lipopolysaccharide 2
Allele Symbol Ticam1Lps2
MGI Allele Accession ID MGI:2679794
Allele synonyms: Lps, Lps2-, Ticam1-, TRIF-, TrifLps2, Trifm
Mutant Construction Technique None
Phenotype
Phenotype Homozygous State Abnormal cytokine secretion: * cytokine secretion induced by naked polyI:C is severely impaired by 5- to 10-fold. * however, secretion induced by transfected polyI:C is unaffected Decreased susceptibility to endotoxin shock: though some mice became ill and died after intraperitoneal LPS injection, the survival rate was significantly greater than that of wild-type. Increased susceptibility to viral infection: no production of type I interferons in response to mouse cytomegalovirus (mCMV).
Original Genetic Background C57BL/6
Genetic Background Currently Maintained C57BL/6
Strain identification
How is this strain characterised? Genotyping
PCR protocols LPS2 (amplifluor)
Fertility and Strain maintenance
Fertility and Strain maintenance
Relevant bibliographic / database references
Strain Specific References
Other Related References
General information
Associated IP rights? Unknown
Does it Model a Human Condition? Unknown
Applicable Research Areas Immunology and inflammation
Keywords
  • ENU
  • Toll like receptor
  • LPS
  • endotoxin
  • MyD88
  • cytokine
Is the strain available in any form to other researchers No
APB stock stored as: Cryopreserved sperm (from 6 mice)

APB stock genotyped verified by: Unverified
Are live mice available? No
MTA needs to be signed? Yes


   

 


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