Mouse Strain information
APB ID 4979
Added 22/01/2010
Last Edited 11/05/2014
Strain name: C57BL/6JAnu-Xrcc6avon/AnuApb
Nickname: Avon ; ENU11B6:178a
Strain designation name: C57BL/6JAnu-Xrcc6avon/AnuApb
Strain Types Mutant strain
Genetic Details Chemically induced : ENU
Mode of Inheritance Recessive
1.  Affected Gene Name: X-ray repair complementing defective repair in Chinese hamster cells 6  
Chromosome 15
Affected Gene Symbol Xrcc6
Genetic alteration of gene: ENU-induced mutation
Location on chromosome (bp): 81846825-81870514 bp, + strand (From Ensembl annotation of NCBI Build 37)
MGI Gene Accession ID

Please also use this link to determine if other mutants have been registered with MGI (Mouse Genome Informatics)

Synonyms G22p1, Ku p70, Ku70
Allele Name avon
Allele Symbol Xrcc6avon
MGI Allele Accession ID MGI:4458398
Ensembl Gene ID: ENSMUSG00000022471
Transcript ID: ENSMUST00000069530
Transcript name: Xrcc6-201
bp change: T to C at position 1494 on cDNA
Exon number: 10
Exon ID: ENSMUSE00000127289
cDNA position: 1494
Amino acid change: Leucine to Proline at position 467
Version: NCBI m37, Ensembl build 56
Mutant Construction Technique None
Phenotype Homozygous State Very low B and T cell numbers in peripheral blood and spleen. Phenotype similar to Rag1 KO.
Phenotype Heterozygous State Normal
Original Genetic Background C57BL/6JAnu
Genetic Background Currently Maintained C57BL/6JAnu
Strain identification
How is this strain characterised? Phenotyping
Phenotyping technique: FACS
Fertility and Strain maintenance
Fertility and Strain maintenance
Relevant bibliographic / database references
General information
Associated IP rights? Unknown
Does it Model a Human Condition? Unknown
Applicable Research Areas Immunology and inflammation
Cell biology
  • B cell
  • T cell
  • immunocompromise
  • differentiation
  • NIH
Is the strain available in any form to other researchers Yes
APB stock stored as: Cryopreserved sperm (from 8 mice)

APB stock genotyped verified by: Unverified
Are live mice available? Unknown
MTA needs to be signed? Yes



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