Mouse Strain information
APB ID 4588
Added 11/03/2009
Last Edited 10/05/2014
Strain nomenclature: C57BL/6JAnu-Cd4sesh/AnuApb
Nickname: Seshat ; ENU11B6:169b
Strain designation name: C57BL/6JAnu-Cd4sesh/AnuApb
Genetics
Strain Types Mutant strain
Genetic Details Chemically induced : ENU
Mode of Inheritance Recessive
1.  Affected Gene Name: CD4 antigen  
Chromosome 6
Affected Gene Symbol Cd4
Protein expression of altered gene: Unknown
Genetic alteration of gene: ENU-Induced mutation.
Location on chromosome (bp): 124814710-124838239 bp, - strand (From VEGA annotation of NCBI Build 37)
MGI Gene Accession ID

Please also use this link to determine if other mutants have been registered with MGI (Mouse Genome Informatics)

 MGI:88335
Synonyms L3T4, Ly-4
Allele Name seshat
Allele Symbol Cd4sesh
MGI Allele Accession ID MGI:4819228
Ensembl Gene ID: ENSMUSG00000023274
Transcript ID: ENSMUST00000024044
Transcript name: Cd4-001
bp change: T to C at position 543 on cDNA
Exon number: 4
Exon ID: ENSMUSE00000246632
cDNA position: 543
Amino acid change: Valine to Alanine at position 125
Sequence:
513AGAACAGGAAAGAGGAGGTGGAGTTGTGGGTGTTCAAAGTGACCTTCAGTCCGGGTACCAGcDNA (forward strand)
115E--N--R--K--E--E--V--E--L--W--V--F--K--V--T--F--S--P--G--T--Sprotein
Version: NCBI m37, Ensembl build 56
Mutant Construction Technique None
Phenotype
Phenotype Homozygous State Reduced T cell numbers in peripheral blood. Reduced CD4 expression.
Original Genetic Background C57BL/6JAnu
Genetic Background Currently Maintained C57BL/6JAnu
Coat Colour Black
Strain Images


Strain identification
How is this strain characterised? Genotyping
PCR protocols 11B6 169b (amplifluor)
Fertility and Strain maintenance
Fertility and Strain maintenance
Relevant bibliographic / database references
General information
Associated IP rights? No
Does it Model a Human Condition? Unknown
Applicable Research Areas Immunology and inflammation
Keywords
  • T cell
  • CD4
  • CD8
  • ENU
  • NIH
  • Wellcome Trust
Is the strain available in any form to other researchers Yes
APB stock stored as: Cryopreserved sperm (from 10 mice)

APB stock genotyped verified by: The depositor
Are live mice available? Unknown
MTA needs to be signed? Yes


     

 


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