Mouse Strain information
APB ID 4514
Added 26/02/2009
Last Edited 10/05/2014
Strain name: C57BL/6JAnu-Cd4theb/AnuApb
Nickname: Thebes ; ENU7B6:039 (CD4)
Strain designation name: C57BL/6JAnu-Cd4theb/AnuApb
Genetics
Strain Types Mutant strain
Genetic Details Chemically induced : ENU
Mode of Inheritance Recessive
1.  Affected Gene Name: CD4 antigen  
Chromosome 6
Affected Gene Symbol Cd4
Protein expression of altered gene: Unknown
Genetic alteration of gene: ENU-induced mutation
Location on chromosome (bp): 124814710-124838239 bp, - strand (From VEGA annotation of NCBI Build 37)
MGI Gene Accession ID

Please also use this link to determine if other mutants have been registered with MGI (Mouse Genome Informatics)

MGI:88335
Synonyms L3T4, Ly-4
Allele Name CD4 antigen; thebes
Allele Symbol Cd4theb
MGI Allele Accession ID MGI:5007797
Allele synonyms: ENU7B6:039 (CD4)
Ensembl Gene ID: ENSMUSG00000023274
Transcript ID: ENSMUST00000024044
Transcript name: Cd4-001
bp change: G to T at position 508 on cDNA
Exon number: 4
Exon ID: ENSMUSE00000246632
cDNA position: 508
Amino acid change: Glutamic acid to Aspartic acid at position 112
Sequence:
478GATGGAAGACTCTCAGACTTATATCTGTGAGCTGGAGAACAGGAAAGAGGAGGTGGAGTTGcDNA (forward strand)
103--M--E--D--S--Q--T--Y--I--C--E--L--E--N--R--K--E--E--V--E--L-protein
Version: NCBI m37, Ensembl build 56
Mutant Construction Technique None
Phenotype
Phenotype Homozygous State Reduced CD4 expression
Original Genetic Background C57BL/6
Genetic Background Currently Maintained C57BL/6JAnu
Strain identification
How is this strain characterised? Genotyping
Phenotyping
Fertility and Strain maintenance
Fertility and Strain maintenance
Relevant bibliographic / database references
General information
Associated IP rights? No
Does it Model a Human Condition? Unknown
Applicable Research Areas Immunology and inflammation
Keywords
  • autoimmunity
  • antinuclear antibodies (ANA)
  • ENU
  • Wellcome Trust
  • CD4
Additional Information Discovered by Wellcome Trust Strategic Award screen for antinuclear autoantibodies by Heather Domaschenz and Dr Lina Tze (JCSMR, ANU). Project guided by Prof Chris Goodnow.
Is the strain available in any form to other researchers Yes
APB stock stored as: Cryopreserved sperm (from 14 mice)
Are live mice available? No
MTA needs to be signed? Yes


   

 


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