Home - Australian Phenomics Facility

Mouse Strain information

APB ID

4514

Added

26/02/2009

Last Edited

05/04/2020

Strain nomenclature:

B6JAnu;CBA-Cd4theb/AnuApb

Nickname:

Thebes ; ENU7B6:039 (CD4)

Strain designation name:

B6JAnu;CBA-Cd4theb/AnuApb

Genetics

Strain Types

Mutant strain

Genetic Details

Chemically induced : ENU

Mode of Inheritance

Recessive

1. Affected Gene Name: CD4 antigen

Chromosome

Affected Gene Symbol

Cd4

Protein expression of altered gene:

Unknown

Genetic alteration of gene:

ENU-induced mutation

Location on chromosome (bp):

124814710-124838239 bp, - strand (From VEGA annotation of NCBI Build 37)

MGI Gene Accession ID

Please also use this link to determine if other mutants have been registered with MGI (Mouse Genome Informatics)

MGI:88335

Synonyms

L3T4, Ly-4

Allele Name

CD4 antigen; thebes

Allele Symbol

Cd4theb

MGI Allele Accession ID

MGI:5007797

Allele synonyms:

ENU7B6:039 (CD4)

Ensembl Gene ID:

ENSMUSG00000023274

Transcript ID:

ENSMUST00000024044

Transcript name:

Cd4-001

bp change:

G to T at position 508 on cDNA

Exon number:

Exon ID:

ENSMUSE00000246632

cDNA position:

508

Amino acid change:

Glutamic acid to Aspartic acid at position 112

Sequence:
478	GATGGAAGACTCTCAGACTTATATCTGTGAGCTGGAGAACAGGAAAGAGGAGGTGGAGTTG	cDNA (forward strand)
103	--M--E--D--S--Q--T--Y--I--C--E--L--E--N--R--K--E--E--V--E--L-	protein

Version:

NCBI m37, Ensembl build 56

Mutant Construction Technique

None

Phenotype

Phenotype Homozygous State

Reduced CD4 expression

Original Genetic Background

B6 x CBA

Genetic Background Currently Maintained

B6 x CBA

Strain identification

How is this strain characterised?

Genotyping
Phenotyping

Fertility and Strain maintenance

Fertility and Strain maintenance

Relevant bibliographic / database references

General information

Associated IP rights?

Does it Model a Human Condition?

Unknown

Applicable Research Areas

Immunology and inflammation

Keywords

autoimmunity
antinuclear antibodies (ANA)
ENU
Wellcome Trust
CD4

Additional Information

Discovered by Wellcome Trust Strategic Award screen for antinuclear autoantibodies by Heather Domaschenz and Dr Lina Tze (JCSMR, ANU). Project guided by Prof Chris Goodnow.

Is the strain available in any form to other researchers

Yes

APB stock stored as:

Cryopreserved sperm (from 14 mice)

Are live mice available?

MTA needs to be signed?

Yes