Mouse Strain information
APB ID 45
Added 06/02/2006
Last Edited 11/05/2014
Strain name: C57BL/6JSfdAnu-Tap2jas/AnuApb
Nickname: Jasmine
Strain designation name: C57BL/6JSfdAnu-Tap2jas/AnuApb
Genetics
Strain Types Mutant strain
Coisogenic
Genetic Details Chemically induced : ENU
Mode of Inheritance Recessive
1.  Affected Gene Name: transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)  
Chromosome 17
Affected Gene Symbol Tap2
Protein expression of altered gene: Normal
Genetic alteration of gene: ENU induced mutation
Location on chromosome (bp): 34203527-34216321 bp, + strand From VEGA annotation of GRCm38
MGI Gene Accession ID

Please also use this link to determine if other mutants have been registered with MGI (Mouse Genome Informatics)

MGI:98484
Synonyms ABC18, Abcb3, Ham-2, HAM2, Ham2, MTP2, PSF-2, PSF2, RING11, Tap-2, Y1
Allele Name jasmine
Allele Symbol Tap2jas
MGI Allele Accession ID MGI:3611893
Ensembl Gene ID: ENSMUSG00000024339
Transcript ID: ENSMUST00000025197
Transcript name: Tap2-001
bp change: A to C at position 1292 on cDNA
Exon number: 5
Exon ID: ENSMUSE00000141074
cDNA position: 1292
Amino acid change: Threonine to Proline at position 292
Sequence:
1262TTCTTCATGCTCCAGGTATCGCCCCGACTCACCTTCCTCTCCCTGCTGGACCTGCCCCTCAcDNA (forward strand)
282-F--F--M--L--Q--V--S--P--R--L--T--F--L--S--L--L--D--L--P--L--protein
Version: NCBI m37, Ensembl build 57
Mutant Construction Technique None
Phenotype
Phenotype Homozygous State No CD8⁺ T cells. Normal CD4⁺ and B cells
Original Genetic Background C57BL/6JSfdAnu
Genetic Background Currently Maintained C57BL/6JSfdAnu
Coat Colour Black
Strain identification
How is this strain characterised? Genotyping
Fertility and Strain maintenance
Fertility and Strain maintenance
Relevant bibliographic / database references
Strain Specific References
Other Related References
General information
Associated IP rights? No
Does it Model a Human Condition? Yes
Description of human condition: Bare Lymphocyte syndrome type 1
Applicable Research Areas Immunology and inflammation
Keywords
  • Tap2
  • T cell
  • CD8
  • CD4
  • ENU
  • Tap1
  • Bare Lymphocyte syndrome type 1
Is the strain available in any form to other researchers Yes
APB stock stored as: Cryopreserved sperm (from 10 mice)

APB stock genotyped verified by: Unverified
Are live mice available? Unknown
MTA needs to be signed? Yes


   

 


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