Mouse Strain information
APB ID 3689
Added 26/08/2008
Last Edited 11/05/2014
Strain name: C57BL/6JAnu-Tap1rose/AnuApb
Nickname: Rose ; ENU11B6:058b
Strain designation name: C57BL/6JAnu-Tap1rose/AnuApb
Genetics
Strain Types Mutant strain
Genetic Details Chemically induced : ENU
Mode of Inheritance Recessive
1.  Affected Gene Name: transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)  
Chromosome 17
Affected Gene Symbol Tap1
Protein expression of altered gene: Unknown
Genetic alteration of gene: ENU-induced mutation
Location on chromosome (bp): 34324825-34333744 bp, + strand (From NCBI annotation of NCBI Build 37)
MGI Gene Accession ID

Please also use this link to determine if other mutants have been registered with MGI (Mouse Genome Informatics)

MGI:98483
Synonyms Abcb2, Ham-1, Ham1, MTP1, PSF-1, RING4, TAP, Tap-1
Allele Name Rose
Allele Symbol Tap1rose
MGI Allele Accession ID MGI:3797750
Ensembl Gene ID: ENSMUSG00000037321
Transcript ID: ENSMUST00000041633
Transcript name: Tap1-201
bp change: A to T at position 2074 on cDNA
Exon number: 10
Exon ID: ENSMUSE00000296635
cDNA position: 2074
Amino acid change: Aspartic acid to Valine at position 643
Sequence:
2044TGATCCGGAAGCCACTCCTGCTTATCTTGGATGATGCCACCAGTGCCCTGGATGCTGGCAAcDNA (forward strand)
633L--I--R--K--P--L--L--L--I--L--D--D--A--T--S--A--L--D--A--G--Nprotein
Version: NCBI m37, Ensembl build 57
Mutant Construction Technique None
Phenotype
Phenotype Homozygous State Very low CD8+ T cell numbers. Mice homozygous for targeted mutations that inactivate the gene are deficient in antigen presentation, surface class I antigens, and CD4-8+ T cells.
Original Genetic Background C57BL/6JAnu
Genetic Background Currently Maintained C57BL/6jAnu
Strain Images
FACS plot from affected (#3, 5) animals compared to unaffected siblings
FACS plot from affected (#3, 5) animals compared to unaffected siblings
Strain identification
How is this strain characterised? Genotyping
PCR protocols 11B6 58 (amplifluor)
Fertility and Strain maintenance
Fertility and Strain maintenance
Relevant bibliographic / database references
Strain Specific References
Other Related References
General information
Associated IP rights? No
Does it Model a Human Condition? Unknown
Applicable Research Areas Immunology and inflammation
Keywords
  • T cell
  • CD8
  • presentation
  • ENU
  • NIH
Is the strain available in any form to other researchers Yes
APB stock stored as: Cryopreserved sperm (from 10 mice)

APB stock genotyped verified by: The APF
Are live mice available? Unknown
MTA needs to be signed? Yes


   

 


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