Mouse Strain information
APB ID 346
Added 25/09/2006
Last Edited 04/06/2017
Strain name: NOD.Cg-Tnfrsf1atm1Blt Faslpr/Apb
Nickname: NODlprT° (2004)
Strain designation name: NOD.Cg-Tnfrsf1atm1Blt Faslpr/Apb
Genetics
Strain Types Mutant strain
Congenic
Genetic Details Spontaneous
Targeted knockout
Mode of Inheritance Recessive
1.  Affected Gene Name: Fas (TNF receptor superfamily member)  
Chromosome 19
Affected Gene Symbol Fas
Protein expression of altered gene: Reduced
Genetic alteration of gene: Southern blotting experiments indicated that the mutation is a genomic rearrangement within the gene, probably within intron 2.
Location on chromosome (bp): 34365199-34402260 bp, + strand (From Ensembl annotation of NCBI Build 37)
MGI Gene Accession ID

Please also use this link to determine if other mutants have been registered with MGI (Mouse Genome Informatics)

MGI:95484
Synonyms APO-1, APT1, CD95, Fas, TNFR6, Tnfrsf6
Allele Name lymphoproliferation
Allele Symbol Faslpr
MGI Allele Accession ID MGI:1856334
Allele synonyms: Fas-, lpr, Tnfrf6lpr, Tnfrsf6lpr, Tnfrsf6lpr
2.  Affected Gene Name: Tumor necrosis family receptor superfamily, member 1a  
Chromosome Unknown
Affected Gene Symbol Tnfrsf1a
Protein expression of altered gene: Unknown
Genetic alteration of gene: A neomycin cassette was used to replace the exons 2, 3, and a portion of 4. The affected exons code for the cysteine-rich domains I and II that are essential for binding of the ligand.
Location on chromosome (bp): 125299380-125312502 bp, + strand (From VEGA annotation of NCBI Build 37)
MGI Gene Accession ID

Please also use this link to determine if other mutants have been registered with MGI (Mouse Genome Informatics)

MGI:1314884
Synonyms CD120a, p55, p55-R, TNF receptor alpha chain, TNF-R-I, TNF-R1, TNF-R55, TNFAR, Tnfr-2, Tnfr1, TNFR60, TNFRp55
Allele Name targeted mutation 1, Horst Bluethmann
Allele Symbol Tnfrsf1atm1Blt
MGI Allele Accession ID MGI:1861040
Allele synonyms: p55-, p55TNFR-, R1KO, Tnfr10, TnfRI-, TNFRp55
Mutant Construction Technique None
Phenotype
Phenotype Homozygous State NODlprT°(2004) homozygotes have lymphadenopathy similar to the NOD.MRL(C3)-Faslpr/LtJ parental strain (see http://jaxmice.jax.org/strain/004519.html for complete details of duplicate stran called NOD.MRL(c3)-Faslpr/DoiJ). This strain also has autoimmune characteristics similar to that seen on the MRL background (e.g. immune complex glomerulonephritis). Thee mice do not develop islet infiltrates. Older mice (20weeks) develop larger livers. (This is possibly a consequence of liver infiltrates blocking vessels)
Phenotype Heterozygous State Similar to NOD/LtJ but there is a possible reduced incidence of diabetes though not formerly tested.
Original Genetic Background Faslpr - MRL/Mp ; Tnfrsf1atm1Blt - 129P2/OlaHsd
Genetic Background Currently Maintained NOD/LtJ
Coat Colour Albino
Strain identification
How is this strain characterised? Genotyping
Fertility and Strain maintenance
Fertility and Strain maintenance
Relevant bibliographic / database references
Strain Specific References
Other Related References
General information
Other Patent Technologies? Contact Hoffman-La Roche for Tnfsrf1a
Associated IP rights? No
Does it Model a Human Condition? Unknown
Research value of this Strain Diabetes and Obesity research Type 1 Diabetes (T1D) Analysis strains (NOD Congenics with Mutations Affecting Immunocompetence) Type 1 Diabetes (T1D) Analysis Strains (NOD/LtJ Non-MHC Congenics)
Applicable Research Areas Diabetes
Cell biology
Research tools
Apoptosis
Developmental biology
Immunology and inflammation
Keywords
  • autoimmunity
  • lymphadenopathy
  • glomerulonephritis
  • lymph node architechture
Additional Information MTA with Hoffman-La Roche required
Is the strain available in any form to other researchers Yes
APB stock stored as: Cryopreserved sperm (from 4 mice)

APB stock genotyped verified by: Unverified
Are live mice available? No
MTA needs to be signed? Yes


   

 


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