Mouse Strain information
APB ID 32
Added 06/02/2006
Last Edited 11/05/2014
Strain name: C57BL/6JSfdAnu-Trp53Bhy/AnuApb
Nickname: B-thy
Strain designation name: C57BL/6JSfdAnu-Trp53Bhy/AnuApb
Genetics
Strain Types Mutant strain
Coisogenic
Genetic Details Chemically induced : ENU
Mode of Inheritance Semi-dominant
1.  Affected Gene Name: transformation related protein 53  
Chromosome 11
Affected Gene Symbol Trp53
Protein expression of altered gene: Nil
Genetic alteration of gene: ENU induced mutation
Location on chromosome (bp): 69580359-69591873 bp, + strand From VEGA annotation of GRCm38
MGI Gene Accession ID

Please also use this link to determine if other mutants have been registered with MGI (Mouse Genome Informatics)

MGI:98834
Synonyms p53
Allele Name bthy
Allele Symbol Trp53Bhy
MGI Allele Accession ID MGI:3611889
Ensembl Gene ID: ENSMUSG00000059552
Transcript ID: ENSMUST00000108658
Transcript name: Trp53-201
bp change: T to C at position 540 on cDNA
Exon number: 5
Exon ID: ENSMUSE00000111826
cDNA position: 540
Amino acid change: Cysteine to Arginine at position 138
Sequence:
510AATAAGCTATTCTGCCAGCTGGCGAAGACGTGCCCTGTGCAGTTGTGGGTCAGCGCCACACcDNA (forward strand)
128-N--K--L--F--C--Q--L--A--K--T--C--P--V--Q--L--W--V--S--A--T--protein
Version: NCBI m37, Ensembl build 55
Mutant Construction Technique None
Phenotype
Phenotype Heterozygous State primitive hematopoietic or T cell leukemia, Sudden death, hemorrhage, Thymic lymphoma Fibrosarcoma Multinodal lymphoma Osteosarcoma Haemangiosarcoma Brain tumour Teratocarcinoma
Original Genetic Background C57BL/6JSfdAnu
Genetic Background Currently Maintained C57BL/6JSfdAnu
Coat Colour Black
Strain identification
How is this strain characterised? Genotyping
PCR protocols B-thy A –D11Mit349 (27.3cM)
B-thy B –D11Mit29 (37.2cM)
Fertility and Strain maintenance
Fertility and Strain maintenance
Relevant bibliographic / database references
General information
Associated IP rights? No
Does it Model a Human Condition? Yes
Applicable Research Areas Cancer
Keywords
  • p53
  • apoptosis
  • tumour
  • cell cycle
  • ENU
Is the strain available in any form to other researchers Yes
APB stock stored as: Cryopreserved sperm (from 6 mice)

APB stock genotyped verified by: Unverified
Are live mice available? No
MTA needs to be signed? Yes


   

 


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