Mouse Strain information
Added 06/02/2006
Last Edited 11/05/2014
Strain name: C57BL/6JSfdAnu-Trp53Bhy/AnuApb
Nickname: B-thy
Strain designation name: C57BL/6JSfdAnu-Trp53Bhy/AnuApb
Strain Types Mutant strain
Genetic Details Chemically induced : ENU
Mode of Inheritance Semi-dominant
1.  Affected Gene Name: transformation related protein 53  
Chromosome 11
Affected Gene Symbol Trp53
Protein expression of altered gene: Nil
Genetic alteration of gene: ENU induced mutation
Location on chromosome (bp): 69580359-69591873 bp, + strand From VEGA annotation of GRCm38
MGI Gene Accession ID

Please also use this link to determine if other mutants have been registered with MGI (Mouse Genome Informatics)

Synonyms p53
Allele Name bthy
Allele Symbol Trp53Bhy
MGI Allele Accession ID MGI:3611889
Ensembl Gene ID: ENSMUSG00000059552
Transcript ID: ENSMUST00000108658
Transcript name: Trp53-201
bp change: T to C at position 540 on cDNA
Exon number: 5
Exon ID: ENSMUSE00000111826
cDNA position: 540
Amino acid change: Cysteine to Arginine at position 138
Version: NCBI m37, Ensembl build 55
Mutant Construction Technique None
Phenotype Heterozygous State primitive hematopoietic or T cell leukemia, Sudden death, hemorrhage, Thymic lymphoma Fibrosarcoma Multinodal lymphoma Osteosarcoma Haemangiosarcoma Brain tumour Teratocarcinoma
Original Genetic Background C57BL/6JSfdAnu
Genetic Background Currently Maintained C57BL/6JSfdAnu
Coat Colour Black
Strain identification
How is this strain characterised? Genotyping
PCR protocols B-thy A –D11Mit349 (27.3cM)
B-thy B –D11Mit29 (37.2cM)
Fertility and Strain maintenance
Fertility and Strain maintenance
Relevant bibliographic / database references
General information
Associated IP rights? No
Does it Model a Human Condition? Yes
Applicable Research Areas Cancer
  • p53
  • apoptosis
  • tumour
  • cell cycle
  • ENU
Is the strain available in any form to other researchers Yes
APB stock stored as: Cryopreserved sperm (from 6 mice)

APB stock genotyped verified by: Unverified
Are live mice available? No
MTA needs to be signed? Yes



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