Mouse Strain information
APB ID 31
Added 06/02/2006
Last Edited 12/06/2014
Strain name: C57BL/6JSfdAnu-Alms1bbb/AnuApb
Nickname: Blobby
Strain designation name: C57BL/6JSfdAnu-Alms1bbb/AnuApb
Genetics
Strain Types Mutant strain
Coisogenic
Genetic Details Chemically induced : ENU
Mode of Inheritance Recessive
1.  Affected Gene Name: Alstrom syndrome 1 homolog (human)  
Chromosome 6
Affected Gene Symbol Alms1
Protein expression of altered gene: Unknown
Genetic alteration of gene: ENU induced mutation
Location on chromosome (bp): 85537525-85652747 bp, + strand (From VEGA annotation of NCBI Build 37)
MGI Gene Accession ID

Please also use this link to determine if other mutants have been registered with MGI (Mouse Genome Informatics)

MGI:1934606
Allele Name blobby
Allele Symbol Alms1bbb
MGI Allele Accession ID MGI:3611799
Ensembl Gene ID: ENSMUSG00000063810
Transcript ID: ENSMUST00000072018
Transcript name: Alms1-001
bp change: T to A at position 6507 on cDNA
Exon number: 10
Exon ID: ENSMUSE00000552223
cDNA position: 6507
Amino acid change: Leucine to STOP at position 2130
Sequence:
6477CTCTTCTTTCTGAAGGTCAGGATTATGAGTTAGAAGAGGTTCAGCATATACCTCAGTCATAcDNA (forward strand)
2121S--L--L--S--E--G--Q--D--Y--E--L--E--E--V--Q--H--I--P--Q--S--Yprotein
Version: NCBI m37, Ensembl build 55
Mutant Construction Technique None
Phenotype
Phenotype Homozygous State Late onset obesity (apparent at 3-6 months). Homozygous null mice display obesity starting after puberty, hypogonadism, hyperinsulinemia, male-specific hyperglycemia, retinal dysfunction, and late-onset hearing loss.
Original Genetic Background C57BL/6JStdAnu
Genetic Background Currently Maintained C57BL/6JStdAnu
Coat Colour Black
Strain identification
How is this strain characterised? Genotyping
PCR protocols BLOBBY
Blobby (amplifluor)
Fertility and Strain maintenance
Fertility and Strain maintenance
Relevant bibliographic / database references
Strain Specific References
Other Related References
General information
Associated IP rights? No
Does it Model a Human Condition? Yes
Research value of this Strain Models human obesity induced by alterations in Alms1 gene
Applicable Research Areas Diabetes
Obesity
Metabolism
Keywords
  • ENU
  • spermatogenesis
  • kidney
  • hyperinsulinemia
Is the strain available in any form to other researchers Yes
APB stock stored as: Cryopreserved sperm (from 13 mice)

APB stock genotyped verified by: The APF
Are live mice available? No
MTA needs to be signed? Yes


   

 


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