Mouse Strain information
APB ID 283
Added 02/05/2006
Last Edited 11/05/2014
Strain name: 129/Sv-Irf1tm1Cwe/Apb
Strain designation name: 129/Sv-Irf1tm1Cwe
Genetics
Strain Types Mutant strain
Genetic Details Targeted knockout
Mode of Inheritance Recessive
1.  Affected Gene Name: interferon regulatory factor 1  
Chromosome 11
Affected Gene Symbol Irf1
Protein expression of altered gene: Unknown
Genetic alteration of gene: Disruption caused by insertion of vector: Sequence extending from nucleotide 752 (within exon 4) to nucleotide 1061 (within exon 6) including 308 bp of coding sequence was replaced by a cassette containing neo and a transcription terminating upstream mouse sequence (UMS).
Location on chromosome (bp): 53583516-53591876 bp, + strand (From VEGA annotation of NCBI Build 37)
MGI Gene Accession ID

Please also use this link to determine if other mutants have been registered with MGI (Mouse Genome Informatics)

MGI:96590
Synonyms Irf-1
Allele Name targeted mutation 1, Charles Weissmann
Allele Symbol Irf1tm1Cwe
MGI Allele Accession ID MGI:2429553
Allele synonyms: IRF-1-, IRF-10/+
Mutant Construction Technique None
Phenotype
Phenotype Homozygous State Immune system abnormal T cell proliferation: higher background proliferation rates hyperproliferation requires higher MOGp35-55 peptide concentrations as a stimulus abnormal cytokine level: lower expression of lymphotoxin alpha and lymphotoxin beta after stimulation with anti-CD3 antibody or with MOGp35-55 peptide decreased circulating interferon-gamma level: levels are reduced relative to controls after stimulation with anti-CD3 antibody or with MOGp35-55 peptide abnormal circulating interleukin-10 level: detectable levels after stimulation with anti-CD3 antibody or with MOGp35-55 peptide increased circulating interleukin-13 level: after stimulation with anti-CD3 antibody or with MOGp35-55 peptide abnormal circulating interleukin-4 level: detectable levels after stimulation with anti-CD3 antibody or with MOGp35-55 peptide increased circulating interleukin-5 level: after stimulation with anti-CD3 antibody or with MOGp35-55 peptide increased circulating interleukin-6 level: after stimulation with anti-CD3 antibody or with MOGp35-55 peptide decreased susceptibility to experimental autoimmune encephalomyelitis: develop an attenuated disease after injection with MOGp35-55 disease onset delayed about 4 days Hematopoietic system abnormal T cell proliferation: higher background proliferation rates hyperproliferation requires higher MOGp35-55 peptide concentrations as a stimulus Homeostasis/metabolism Abnormal cytokine level: lower expression of lymphotoxin alpha and lymphotoxin beta after stimulation with anti-CD3 antibody or with MOGp35-55 peptide decreased circulating interferon-gamma level: levels are reduced relative to controls after stimulation with anti-CD3 antibody or with MOGp35-55 peptide abnormal circulating interleukin-10 level: detectable levels after stimulation with anti-CD3 antibody or with MOGp35-55 peptide increased circulating interleukin-13 level: after stimulation with anti-CD3 antibody or with MOGp35-55 peptide abnormal circulating interleukin-4 level: detectable levels after stimulation with anti-CD3 antibody or with MOGp35-55 peptide increased circulating interleukin-5 level: after stimulation with anti-CD3 antibody or with MOGp35-55 peptide increased circulating interleukin-6 level: after stimulation with anti-CD3 antibody or with MOGp35-55 peptide
Original Genetic Background 129
Genetic Background Currently Maintained 129/Sv
Strain identification
How is this strain characterised? Genotyping
Fertility and Strain maintenance
Fertility and Strain maintenance
Relevant bibliographic / database references
Strain Specific References
Other Related References
General information
Associated IP rights? No
Does it Model a Human Condition? Unknown
Applicable Research Areas Haematology
Cell biology
Immunology and inflammation
Keywords
  • interferon
  • T cell
  • CD4, CD8
  • iNOS
Additional Information Written permission required from Charles Weissman prior to access.
Is the strain available in any form to other researchers Yes
APB stock stored as: Cryopreserved sperm (from 9 mice)

APB stock genotyped verified by: The depositor
Are live mice available? No
MTA needs to be signed? Yes


   

 


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