Home - Australian Phenomics Facility

Mouse Strain information

APB ID

Added

06/02/2006

Last Edited

10/05/2014

Strain nomenclature:

STOCK H2k2 Dsg4arm/AnuApb

Nickname:

Armadillo

Strain designation name:

STOCK H2k2 Dsg4arm/AnuApb

Genetics

Strain Types

Mutant strain

Genetic Details

Chemically induced : ENU

Mode of Inheritance

Recessive

1. Affected Gene Name: desmoglein 4

Chromosome	18
Affected Gene Symbol	Dsg4
Protein expression of altered gene:	Unknown
Genetic alteration of gene:	ENU induced mutation. Exon 4 is deleted however the base pair mutation has not been located.
Location on chromosome (bp):	20594676-20630322 bp, + strand (From VEGA annotation of NCBI Build 37)
MGI Gene Accession ID Please also use this link to determine if other mutants have been registered with MGI (Mouse Genome Informatics)	MGI:2661061
Synonyms	CDHF13, lah
Allele Name	armadillo
Allele Symbol	Dsg4arm
MGI Allele Accession ID	MGI:3846150

1. Affected Congenic Gene Name: histocompatibility-2, MHC

Mutant Construction Technique

None

Phenotype

Phenotype Homozygous State

Hairless and wrinkly. The Armadillo mice have a very short hair coat all over the body. The short hair is most pronounced on the extremities, eg. Ears, tail, muzzle and limbs up to the hock and elbow, and ventrally. The hair dorsally looks more normal, but it appears to lack guard hairs. This appearance is possibly due to breakage of all hair follicles causing an overall shorter appearance to the coat. The skin also appears slightly hyperaemic (reddened), but this could just be due to less hair coverage. The affected mice appear to have no whiskers and are also smaller than normal littermates. On histology, the most obvious feature is generalised epidermal hyperplasia. The affected mice also have an "onion bulb" appearance to the base of the hair follicle. Above this is an area of bright orange/pink staining which suggests premature cornification of the hair shaft and adjacent inner root sheath. Some mice had a mild neutrophilic infiltrate into the dermis and some mice had focal pink swellings of the hair fibres. The hair follicle produced is abnormal and prone to breakage resulting in short hair.

Original Genetic Background

C57BL/6JSfdAnu

Genetic Background Currently Maintained

C57BL/6JSfdAnu x B10.BR-H2k2

Coat Colour

Sparse coat

Strain Images

Affected individual

Strain identification

How is this strain characterised?

Phenotyping

Phenotyping technique:

Physical appearance of coat

Fertility and Strain maintenance

Fertility and Strain maintenance

	Female	Male
Are homozygous mice viable?	Yes	Yes
Are homozygous mice fertile?	Yes	Yes
*Are heterozygotes / hemizygotes fertile?**	Yes	Yes
* Hemizygote as used here refers to males carring a mutation on the X chromosome or mice of either sex carrying an inserted transgene with no homologous allele on the other chromosome.
Sib-Mated Generations	6
Mating Scheme	Affected male by unaffected female
Homozygous Matings Required?	No
Percentage of Female Homozygous Mice Surviving to Maturity	100.0
Age of Reproductive Maturity	6 weeks
Male Fertility Compromised?	No
Average Number of Pups at Birth	5.0
Average Number of Pups Surviving to Weaning	5.0
Weaning Age	21 days
Breeding Performance	Good

Relevant bibliographic / database references

Strain Specific References

Other Related References

General information

Associated IP rights?

Does it Model a Human Condition?

Unknown

Applicable Research Areas

Dermatology
Developmental biology

Keywords

Hair
Coat
Epidermis
follicle
ENU

Is the strain available in any form to other researchers

Yes

APB stock stored as:

Cryopreserved sperm (from 8 mice)

APB stock genotyped verified by:

Unverified

Are live mice available?

MTA needs to be signed?

Yes