Mouse Strain information
APB ID 28
Added 06/02/2006
Last Edited 10/05/2014
Strain name: STOCK H2k2 Dsg4arm/AnuApb
Nickname: Armadillo
Strain designation name: STOCK H2k2 Dsg4arm/AnuApb
Genetics
Strain Types Mutant strain
Genetic Details Chemically induced : ENU
Mode of Inheritance Recessive
1.  Affected Gene Name: desmoglein 4  
Chromosome 18
Affected Gene Symbol Dsg4
Protein expression of altered gene: Unknown
Genetic alteration of gene: ENU induced mutation. Exon 4 is deleted however the base pair mutation has not been located.
Location on chromosome (bp): 20594676-20630322 bp, + strand (From VEGA annotation of NCBI Build 37)
MGI Gene Accession ID

Please also use this link to determine if other mutants have been registered with MGI (Mouse Genome Informatics)

MGI:2661061
Synonyms CDHF13, lah
Allele Name armadillo
Allele Symbol Dsg4arm
MGI Allele Accession ID MGI:3846150
1.  Affected Congenic Gene Name: histocompatibility-2, MHC  
Mutant Construction Technique None
Phenotype
Phenotype Homozygous State Hairless and wrinkly. The Armadillo mice have a very short hair coat all over the body. The short hair is most pronounced on the extremities, eg. Ears, tail, muzzle and limbs up to the hock and elbow, and ventrally. The hair dorsally looks more normal, but it appears to lack guard hairs. This appearance is possibly due to breakage of all hair follicles causing an overall shorter appearance to the coat. The skin also appears slightly hyperaemic (reddened), but this could just be due to less hair coverage. The affected mice appear to have no whiskers and are also smaller than normal littermates. On histology, the most obvious feature is generalised epidermal hyperplasia. The affected mice also have an "onion bulb" appearance to the base of the hair follicle. Above this is an area of bright orange/pink staining which suggests premature cornification of the hair shaft and adjacent inner root sheath. Some mice had a mild neutrophilic infiltrate into the dermis and some mice had focal pink swellings of the hair fibres. The hair follicle produced is abnormal and prone to breakage resulting in short hair.
Original Genetic Background C57BL/6JSfdAnu
Genetic Background Currently Maintained C57BL/6JSfdAnu x B10.BR-H2k2
Coat Colour Sparse coat
Strain Images
Affected individual
Affected individual
Strain identification
How is this strain characterised? Phenotyping
Phenotyping technique: Physical appearance of coat
Fertility and Strain maintenance
Fertility and Strain maintenance
Relevant bibliographic / database references
Strain Specific References
Other Related References
General information
Associated IP rights? No
Does it Model a Human Condition? Unknown
Applicable Research Areas Developmental biology
Dermatology
Keywords
  • Hair
  • Coat
  • Epidermis
  • follicle
  • ENU
Is the strain available in any form to other researchers Yes
APB stock stored as: Cryopreserved sperm (from 8 mice)

APB stock genotyped verified by: Unverified
Are live mice available? No
MTA needs to be signed? Yes


   

 


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