Mouse Strain information
APB ID 2767
Added 15/02/2008
Last Edited 11/05/2014
Strain name: BALB/c-Fliitm1Hdc Tg(FLII)1Hdc/AnuApb
Nickname: BALB/c.Flii-/- FLIIc110H8/c110H8 ; FICR
Strain designation name: BALB/c-Fliitm1Hdc Tg(FLII)1Hdc
Genetics
Strain Types Mutant strain
Coisogenic
Genetic Details Targeted knockout
Transgenic: BAC
Mode of Inheritance Recessive
1.  Affected Gene Name: flightless I homolog (Drosophila)  
Chromosome 11
Affected Gene Symbol Flii
Protein expression of altered gene: Unknown
Genetic alteration of gene: Portions of exons 4 and 5 and all of intron 4 are replaced with an in-frame neo-resistance gene. Cryptic splicing around the insertion will result in a frameshift in the coding region.
Location on chromosome (bp): 60527625-60540765 bp, - strand (From VEGA annotation of NCBI Build 37)
MGI Gene Accession ID

Please also use this link to determine if other mutants have been registered with MGI (Mouse Genome Informatics)

MGI:1342286
Synonyms Fli1, Fliih
Allele Name targeted mutation 1, Hugh D Campbell
Allele Symbol Fliitm1Hdc
MGI Allele Accession ID MGI:2179825
Allele synonyms: FliI-, Fliih-
1.   Transgene: transgene insertion 1, Hugh D Campbell  
Mutant Construction Technique None
Phenotype
Phenotype Homozygous State Embryonic lethal phenotype of FLii knockout is rescued by human FLII transgene. Ubiquitous expression of human Flightless gene.
Original Genetic Background BALB/c
Genetic Background Currently Maintained BALB/c
Coat Colour White
Eye Colour Red
Strain identification
How is this strain characterised? Genotyping
PCR protocols Flii Knockout
Flii
Fertility and Strain maintenance
Fertility and Strain maintenance
Relevant bibliographic / database references
Strain Specific References
Other Related References
General information
Associated IP rights? No
Does it Model a Human Condition? Unknown
Applicable Research Areas Dermatology
Developmental biology
Keywords
  • human flightless
  • wound repair
  • cellular proliferation
  • cell migration
  • gelsolin
Is the strain available in any form to other researchers Yes
APB stock stored as: Cryopreserved sperm (from 8 mice)

APB stock genotyped verified by: Unverified
Are live mice available? Unknown
MTA needs to be signed? Yes


   

 


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