Mouse Strain information
APB ID 251
Added 28/04/2006
Last Edited 11/05/2014
Strain name: 129-Ccr1tm1Cge/Apb
Strain designation name: 129-Ccr1tm1Cge/Apb
Genetics
Strain Types Mutant strain
Genetic Details Targeted knockout
Mode of Inheritance Recessive
1.  Affected Gene Name: chemokine (C-C motif) receptor 1  
Chromosome 9
Affected Gene Symbol Ccr1
Protein expression of altered gene: Nil
Genetic alteration of gene: A PGK-neomycin resistance cassette replaced most of the carboxy terminal coding sequence. Transcript was not detected in bone marrow cells of homozygous mutant animals
Location on chromosome (bp): 123876957-123883399 bp, - strand (From NCBI annotation of NCBI Build 37)
MGI Gene Accession ID

Please also use this link to determine if other mutants have been registered with MGI (Mouse Genome Informatics)

MGI:104618
Synonyms Cmkbr1, MIP-1 alphaR, Mip-1a-R
Allele Name targeted mutation 1, Craig Gerard
Allele Symbol Ccr1tm1Cge
MGI Allele Accession ID MGI:1931849
Mutant Construction Technique None
Phenotype
Phenotype Homozygous State Homozygotes for targeted null mutations exhibit altered trafficking and proliferation of myeloid progenitor cells, and impairments in granulomatous inflammation of the lung and neutrophil associated host defense.
Genetic Background Currently Maintained 129
Strain identification
How is this strain characterised? Genotyping
Fertility and Strain maintenance
Fertility and Strain maintenance
Relevant bibliographic / database references
Strain Specific References
Other Related References
General information
Associated IP rights? No
Does it Model a Human Condition? Unknown
Applicable Research Areas Haematology
Immunology and inflammation
Keywords
  • chemokine
  • RANTES
  • neutrophil
  • inflammation
Additional Information Control strain also cryopreserved
Is the strain available in any form to other researchers Yes
APB stock stored as: Cryopreserved sperm (from 5 mice)

APB stock genotyped verified by: Unverified
Are live mice available? Unknown
MTA needs to be signed? Yes


   

 


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