Mouse Strain information
APB ID 246
Added 26/04/2006
Last Edited 11/05/2014
Strain name: B6.129S2-B2mtm1Jae/AnuApb
Nickname: B6.B2m-/-
Strain designation name: B6.129S2-B2mtm1Jae/AnuApb
Genetics
Strain Types Mutant strain
Genetic Details Targeted knockout
Mode of Inheritance Recessive
1.  Affected Gene Name: beta-2 microglobulin  
Chromosome 2
Affected Gene Symbol B2m
Protein expression of altered gene: Nil
Genetic alteration of gene: A neomycin resistance cassette was inserted into the second exon.
Location on chromosome (bp): 121973422-121978819 bp, + strand (From VEGA annotation of NCBI Build 37)
MGI Gene Accession ID

Please also use this link to determine if other mutants have been registered with MGI (Mouse Genome Informatics)

MGI:88127
Synonyms beta 2 microglobulin, beta2-m, Ly-m11
Allele Name targeted mutation 1, Rudolf Jaenisch
Allele Symbol B2mtm1Jae
MGI Allele Accession ID MGI:1927183
Allele synonyms: B2M-, beta2M-, beta2mnull, MHC classI-
Mutant Construction Technique None
Phenotype
Phenotype Homozygous State Homozygotes lacking B2m appear normal, but have no detectable MHC class I antigen on their cells and are deficient in CD4- CD8+ T cells which mediate cytotoxic T cell function. Mutant mice are also subject to systemic iron loading.
Genetic Background Currently Maintained C57BL/6
Strain identification
How is this strain characterised? Genotyping
Fertility and Strain maintenance
Fertility and Strain maintenance
Relevant bibliographic / database references
Strain Specific References
Other Related References
General information
Associated IP rights? No
Does it Model a Human Condition? Yes
Applicable Research Areas Immunology and inflammation
Keywords
  • MHC
  • antigen presentation
  • cytotoxic
  • T cell
  • lymphocyte
Is the strain available in any form to other researchers Yes
APB stock stored as: Cryopreserved sperm (from 11 mice)

APB stock genotyped verified by: The depositor
Are live mice available? Unknown
MTA needs to be signed? Yes


   

 


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