Mouse Strain information
APB ID 2379
Added 14/12/2007
Last Edited 10/05/2014
Strain name: B6JSfdAnu;CBA-Bcl2drn/AnuApb
Nickname: Dorian, ENU6AT:HELxTCR:035
Strain designation name: B6JSfdAnu;CBA-Bcl2drn/AnuApb
Strain Types Mutant strain
Genetic Details Chemically induced : ENU
Mode of Inheritance Recessive
1.  Affected Gene Name: B-cell leukemia/lymphoma 2  
Chromosome 1
Affected Gene Symbol Bcl2
Protein expression of altered gene: Unknown
Genetic alteration of gene: ENU-induced mutation. The mutation comprises a T to C transition at nucleotide position 70 that replaces serine with proline at amino acid position 24 of the protein (S24P).
Location on chromosome (bp): 108434755-108610851 bp, - strand (From VEGA annotation of NCBI Build 37)
MGI Gene Accession ID

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Synonyms Bcl-2
Allele Name B-cell leukemia/lymphoma 2; dorian
Allele Symbol Bcl2drn
MGI Allele Accession ID MGI:3844731
Ensembl Gene ID: ENSMUSG00000057329
Transcript ID: ENSMUST00000080103
Transcript name: Bcl2-201
bp change: T to C at position 1244 on cDNA
Exon number: 2
Exon ID: ENSMUSE00000466735
cDNA position: 1244
Amino acid change: Serine to Proline at position 24
Version: NCBI m37, Ensembl build 56
Mutant Construction Technique None
Phenotype Homozygous State Coat colour change. Diluted coat colour. Irregular coat pigmentation. Affected mice undergo dramatic greying/whitening of their coat from about 4 - 5 weeks of age. Both black and agouti mice are affected. "Salt 'n' Pepper". Mice do not appear to "age" at a greater rate.
Original Genetic Background C57BL/6JStdAnu
Genetic Background Currently Maintained C57BL/6JStdAnu x CBA/CaJ
Coat Colour Black➡grey, white
Strain Images
Affect mouse
Affect mouse
Strain identification
How is this strain characterised? Phenotyping
Fertility and Strain maintenance
Fertility and Strain maintenance
Relevant bibliographic / database references
Strain Specific References
Other Related References
General information
Associated IP rights? No
Does it Model a Human Condition? Unknown
Research value of this Strain Hair development Ageing?
Applicable Research Areas Developmental biology
  • Coat
  • grey
  • salt and pepper
  • ageing
  • ENU
  • hair
  • Bcl2
Is the strain available in any form to other researchers Yes
APB stock stored as: Cryopreserved sperm (from 10 mice)

APB stock genotyped verified by: Unverified
Are live mice available? No
MTA needs to be signed? Yes



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