Mouse Strain information
APB ID 2379
Added 14/12/2007
Last Edited 10/05/2014
Strain name: B6JSfdAnu;CBA-Bcl2drn/AnuApb
Nickname: Dorian, ENU6AT:HELxTCR:035
Strain designation name: B6JSfdAnu;CBA-Bcl2drn/AnuApb
Genetics
Strain Types Mutant strain
Genetic Details Chemically induced : ENU
Mode of Inheritance Recessive
1.  Affected Gene Name: B-cell leukemia/lymphoma 2  
Chromosome 1
Affected Gene Symbol Bcl2
Protein expression of altered gene: Unknown
Genetic alteration of gene: ENU-induced mutation. The mutation comprises a T to C transition at nucleotide position 70 that replaces serine with proline at amino acid position 24 of the protein (S24P).
Location on chromosome (bp): 108434755-108610851 bp, - strand (From VEGA annotation of NCBI Build 37)
MGI Gene Accession ID

Please also use this link to determine if other mutants have been registered with MGI (Mouse Genome Informatics)

MGI:88138
Synonyms Bcl-2
Allele Name B-cell leukemia/lymphoma 2; dorian
Allele Symbol Bcl2drn
MGI Allele Accession ID MGI:3844731
Ensembl Gene ID: ENSMUSG00000057329
Transcript ID: ENSMUST00000080103
Transcript name: Bcl2-201
bp change: T to C at position 1244 on cDNA
Exon number: 2
Exon ID: ENSMUSE00000466735
cDNA position: 1244
Amino acid change: Serine to Proline at position 24
Sequence:
1214ATCGTGATGAAGTACATACATTATAAGCTGTCACAGAGGGGCTACGAGTGGGATGCTGGAGcDNA (reverse strand)
14-I--V--M--K--Y--I--H--Y--K--L--S--Q--R--G--Y--E--W--D--A--G--protein
Version: NCBI m37, Ensembl build 56
Mutant Construction Technique None
Phenotype
Phenotype Homozygous State Coat colour change. Diluted coat colour. Irregular coat pigmentation. Affected mice undergo dramatic greying/whitening of their coat from about 4 - 5 weeks of age. Both black and agouti mice are affected. "Salt 'n' Pepper". Mice do not appear to "age" at a greater rate.
Original Genetic Background C57BL/6JStdAnu
Genetic Background Currently Maintained C57BL/6JStdAnu x CBA/CaJ
Coat Colour Black➡grey, white
Strain Images
Affect mouse
Affect mouse
Strain identification
How is this strain characterised? Genotyping
Phenotyping
Fertility and Strain maintenance
Fertility and Strain maintenance
Relevant bibliographic / database references
Strain Specific References
Other Related References
General information
Associated IP rights? No
Does it Model a Human Condition? Unknown
Research value of this Strain Hair development Ageing?
Applicable Research Areas Developmental biology
Dermatology
Keywords
  • Coat
  • grey
  • salt and pepper
  • ageing
  • ENU
  • hair
  • Bcl2
Is the strain available in any form to other researchers Yes
APB stock stored as: Cryopreserved sperm (from 10 mice)

APB stock genotyped verified by: Unverified
Are live mice available? No
MTA needs to be signed? Yes


   

 


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