Mouse Strain information
APB ID 2377
Added 14/12/2007
Last Edited 10/05/2014
Strain name: C57BL/6Apb-Gdf5png/AnuApb
Nickname: Pengu, ENU8B6:075
Strain designation name: C57BL/6Apb-Gdf5png/AnuApb
Genetics
Strain Types Mutant strain
Genetic Details Chemically induced
Mode of Inheritance Recessive
1.  Affected Gene Name: growth differentiation factor 5  
Chromosome 2
Affected Gene Symbol Gdf5
Protein expression of altered gene: Unknown
Genetic alteration of gene: ENU-induced mutation. Comprises a single-nucleotide substitution in exon 1 that converts the ATG transcription initiation codon to an ACG triplet.
Location on chromosome (bp): 155766759-155771103 bp, - strand (From VEGA annotation of NCBI Build 37)
MGI Gene Accession ID

Please also use this link to determine if other mutants have been registered with MGI (Mouse Genome Informatics)

MGI:95688
Synonyms bp, brp, cartilage-derived morphogenetic protein-1, CDMP-1
Allele Name growth differentiation factor 5; pengu
Allele Symbol Gdf5png
MGI Allele Accession ID MGI:3847115
Ensembl Gene ID: ENSMUSG00000038259
Transcript ID: ENSMUST00000040162
Transcript name: Gdf5-001
bp change: T to C at position 314 on cDNA
Exon number: 1
Exon ID: ENSMUSE00000323175
cDNA position: 314
Amino acid change: Methionine to Threonine at position 1
Sequence:
284TGTGGTGTCATTCAGCGGCTGGCCAGAGGATGAGACTCCCCAAACTCCTCACTCTTTTGCTcDNA (reverse strand)
1.............................-M--R--L--P--K--L--L--T--L--L--Lprotein
Version: NCBI m37, Ensembl build 56
Mutant Construction Technique None
Phenotype
Phenotype Homozygous State Limb deformity. Four shortened limbs with angular deformity, most pronounced in hindlimbs
Original Genetic Background C57BL/6
Genetic Background Currently Maintained C57BL/6
Coat Colour Black
Strain identification
How is this strain characterised? Genotyping
Phenotyping
PCR protocols Pengu (amplifluor)
Fertility and Strain maintenance
Fertility and Strain maintenance
Relevant bibliographic / database references
General information
Associated IP rights? No
Does it Model a Human Condition? Unknown
Applicable Research Areas Developmental biology
Bone
Keywords
  • Limb
  • deformity
  • Brachypodism
  • Feet
  • ENU
Is the strain available in any form to other researchers Yes
APB stock stored as: Cryopreserved sperm (from 5 mice)

APB stock genotyped verified by: Unverified
Are live mice available? No
MTA needs to be signed? Yes


   

 


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