Mouse Strain information
APB ID 2039
Added 21/09/2007
Last Edited 11/05/2014
Strain name: B6;129-Stat1tm1Rds/Apb
Nickname: STAT1 KO
Strain designation name: B6;129-Stat1tm1Rds/Apb
Genetics
Strain Types Mutant strain
Genetic Details Targeted knockout
ES Cell-Line Used GS-1
Mode of Inheritance Recessive
1.  Affected Gene Name: signal transducer and activator of transcription 1  
Chromosome 1
Affected Gene Symbol Stat1
Protein expression of altered gene: Nil
Genetic alteration of gene: A neomycin resistance cassette replaced the first three coding exons and 0.7kb of 5' upstream flanking sequence.
Location on chromosome (bp): 52176282-52218704 bp, + strand (From Ensembl annotation of NCBI Build 37)
MGI Gene Accession ID

Please also use this link to determine if other mutants have been registered with MGI (Mouse Genome Informatics)

MGI:103063
Allele Name targeted mutation 1, Robert D Schreiber
Allele Symbol Stat1tm1Rds
MGI Allele Accession ID MGI:1861949
Mutant Construction Technique None
Phenotype
Phenotype Homozygous State Increased sensitivity to microbial pathogens and viruses due to impaired responsiveness to interferons. Increased Bone mass. Increased osteoclast cell number.
Phenotype Heterozygous State No phenotype reported.
Original Genetic Background C57BL/6
Genetic Background Currently Maintained C57BL/6 x 129/Sv
Coat Colour mixed black and agouti
Strain identification
How is this strain characterised? Genotyping
Fertility and Strain maintenance
Fertility and Strain maintenance
Relevant bibliographic / database references
Strain Specific References
Other Related References
General information
Associated IP rights? No
Does it Model a Human Condition? No
Applicable Research Areas Virology
Models for human disease
Cell biology
Research tools
Apoptosis
Cancer
Immunology and inflammation
Keywords
  • signal transduction
  • cytokine
  • JAK
  • kinase
  • phosphorylation
Is the strain available in any form to other researchers Yes
APB stock stored as: Cryopreserved sperm (from 9 mice)

APB stock genotyped verified by: The depositor
Are live mice available? Unknown
MTA needs to be signed? No


   

 


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