Mouse Strain information
APB ID 2010
Added 17/09/2007
Last Edited 11/05/2014
Strain name: B6;129P2-Stat3tm1Aki/Apb
Nickname: Stat3 heterozygous knockout
Strain designation name: B6;129P2-Stat3tm1Aki
Genetics
Strain Types Mutant strain
Genetic Details Targeted knockout
ES Cell-Line Used E14-1
Mode of Inheritance Recessive
1.  Affected Gene Name: Signal transducer and activator of transcription 3  
Chromosome 11
Affected Gene Symbol Stat3
Protein expression of altered gene: Nil
Genetic alteration of gene: Exons 20, 21, and 22 are replaced with the pMC1-neo gene (Stratagene). This deletion causes a loss of Src homology 2 domain and tyrosine residue, which are essential for activation of STAT proteins.
Location on chromosome (bp): 100746412-100800854 bp, - strand (From VEGA annotation of NCBI Build 37)
MGI Gene Accession ID

Please also use this link to determine if other mutants have been registered with MGI (Mouse Genome Informatics)

MGI:103038
Synonyms Aprf
Allele Name targeted mutation 1, Shizuo Akira
Allele Symbol Stat3tm1Aki
MGI Allele Accession ID MGI:1926814
Mutant Construction Technique None
Phenotype
Phenotype Homozygous State Embryonic lethal (E7.5)
Phenotype Heterozygous State Viable, fertile - no apparent abnormalities.
Original Genetic Background 129Sv x C57BL/6
Genetic Background Currently Maintained 129Sv x C57BL/6
Coat Colour Mixed agouti and black
Strain identification
How is this strain characterised? Genotyping
Fertility and Strain maintenance
Fertility and Strain maintenance
Relevant bibliographic / database references
Strain Specific References
Other Related References
General information
Associated IP rights? No
Does it Model a Human Condition? No
Research value of this Strain This is the only strain available to assess the impact of globally-reduced STAT3 activation in vivo.
Applicable Research Areas Models for human disease
Gastrointestinal
Cell biology
Cardiovascular
Bone
Haematology
Internal/organ
Research tools
Apoptosis
Cancer
Immunology and inflammation
Keywords
  • STAT
  • cytokine
  • transcription
  • interleukin
Is the strain available in any form to other researchers Yes
APB stock stored as: Cryopreserved sperm (from 9 mice)

APB stock genotyped verified by: The depositor
Are live mice available? Unknown
MTA needs to be signed? Yes


   

 


Build: 2017.11.14 Non-profit supported by the Australian government  |  © Copyright 2017 Australian Phenomics Facility Last updated: 16/11/2017