Mouse Strain information
APB ID 1947
Added 01/09/2007
Last Edited 11/05/2014
Strain name: B6;129P2-Tlr4tm1Aki/AnuApb
Nickname: C57BL/6-TLR-4tm1 ; Teague
Strain designation name: B6;129P2-Tlr4tm1Aki
Genetics
Strain Types Mutant strain
Genetic Details Targeted knockout
Mode of Inheritance Recessive
1.  Affected Gene Name: toll-like receptor 4  
Chromosome 4
Affected Gene Symbol Tlr4
Protein expression of altered gene: Nil
Genetic alteration of gene: Genomic sequences encoding the transmembrane and cytoplasmic domains (amino acids 86-835) were replaced with a neomycin cassette. Northern blot analysis revealed that no mRNA is produced from this allele in splenocytes derived from homozygous mice.
Location on chromosome (bp): 66488618-66591318 bp, + strand (From VEGA annotation of NCBI Build 37)
MGI Gene Accession ID

Please also use this link to determine if other mutants have been registered with MGI (Mouse Genome Informatics)

MGI:96824
Synonyms lipopolysaccharide response, Lps, Rasl2-8
Allele Name toll-like receptor 4; targeted mutation 1, Shizuo Akira
Allele Symbol Tlr4tm1Aki
MGI Allele Accession ID MGI:1860885
Allele synonyms: TLR4 KO, TLR4-, TLR4-KO
Mutant Construction Technique None
Phenotype
Phenotype Homozygous State Homozygotes for spontaneous or targeted mutations are hyporesponsive to bacterial lipopolysaccharide and more susceptible to infection by gram negative bacteria.
Genetic Background Currently Maintained C57BL/6
Strain identification
How is this strain characterised? Genotyping
Fertility and Strain maintenance
Fertility and Strain maintenance
Relevant bibliographic / database references
Strain Specific References
Other Related References
General information
Associated IP rights? No
Does it Model a Human Condition? Unknown
Applicable Research Areas Immunology and inflammation
Keywords
  • infection
  • T cell
  • inflammation
  • eosinophil
  • hyperresponsiveness
Is the strain available in any form to other researchers Yes
APB stock stored as: Cryopreserved sperm (from 10 mice)
Are live mice available? Unknown
MTA needs to be signed? Yes


   

 


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