Mouse Strain information
APB ID 1929
Added 23/08/2007
Last Edited 11/05/2014
Strain name: C.129P2-Stat6tm1Aki/AnuApb
Nickname: Balb/C Stat6-/- N10
Strain designation name: C.129P2-Stat6tm1Aki/AnuApb
Genetics
Strain Types Mutant strain
Congenic
Genetic Details Targeted knockout
Mode of Inheritance Recessive
1.  Affected Gene Name: signal transducer and activator of transcription 6  
Chromosome 10
Affected Gene Symbol Stat6
Protein expression of altered gene: Nil
Genetic alteration of gene: The 3 exons encoding the SH2 domain were replaced with a neomycin resistance gene via homologous recombination. Northern blot analysis of splenocytes from homozygous mutant animals using a probe to exons downstream of the deleted region did not detect gene expression.
Location on chromosome (bp): 127080042-127098013 bp, + strand (From Ensembl annotation of NCBI Build 37)
MGI Gene Accession ID

Please also use this link to determine if other mutants have been registered with MGI (Mouse Genome Informatics)

MGI:103034
Synonyms stat6-
Allele Name signal transducer and activator of transcription 6; targeted mutation 1, Shizuo Akira
Allele Symbol Stat6tm1Aki
MGI Allele Accession ID MGI:2386746
Allele synonyms: Stat6-, STAT6KO
Mutant Construction Technique None
Phenotype
Phenotype Homozygous State Skin inflammation: * mice exhibit mild dermal infiltration of inflammatory cells. * few CD4+ cells infiltrate the perioral dermis and epidermis. Acanthosis: sight. Decreased B cell proliferation: * B cell proliferation in response to anti-IgM plus IL-4 is impaired. * however, B cell proliferation in response to LPS is normal. Decreased T cell proliferation: * thymocyte proliferation in response to TPA is impaired. * however, thymocyte proliferate in response to other stimuli. Decreased IgE level: IgE levels are lower than in wild-type mice following infection with N. brasiliensis. Decreased IgG1 level: IgG1 levels are 16-fold lower than in wild-type mice and following infection with N. brasiliensis they are 10-fold lower than in infected wild-type mice. Increased IgA level: IgA levels are slightly increased following infection with N. brasiliensis. Increased IgG level: IgG2 and IgG3 levels are slightly increased following infection with N. brasiliensis. Abnormal T-helper 2 physiology: mice fail to produce increased levels of Th2 cytokines in response to infection with N. brasiliensis.
Original Genetic Background 129
Genetic Background Currently Maintained BALB/c
Strain identification
How is this strain characterised? Genotyping
Fertility and Strain maintenance
Fertility and Strain maintenance
Relevant bibliographic / database references
Strain Specific References
Other Related References
General information
Associated IP rights? No
Does it Model a Human Condition? Unknown
Applicable Research Areas Immunology and inflammation
Keywords
  • T cell
  • IL-4
  • signal transduction
  • lymphocyte
  • B cell
Is the strain available in any form to other researchers Yes
APB stock stored as: Cryopreserved sperm (from 2 mice)

APB stock genotyped verified by: Unverified
Are live mice available? Unknown
MTA needs to be signed? Yes


   

 


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