Mouse Strain information
APB ID 165
Added 15/04/2006
Last Edited 11/05/2014
Strain name: B6.129P2-Cited2tm1Jpmb/Apb
Nickname: C2B6∆
Strain designation name: B6.129P2-Cited2tm1Jpmb/Apb
Genetics
Strain Types Mutant strain
Congenic
Genetic Details Targeted knockin
Targeted reporter
ES Cell-Line Used E14
Mode of Inheritance Recessive
1.  Affected Gene Name: Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2  
Chromosome 10
Affected Gene Symbol Cited2
Protein expression of altered gene: Nil
Genetic alteration of gene: IRES-lacZ-Neo cassette was inserted at 4 amino acids from the ATG and deleted the entire coding region.
Location on chromosome (bp): 17647361-17649768, + strand (From Ensembl annotation of NCBI Build 34)
MGI Gene Accession ID

Please also use this link to determine if other mutants have been registered with MGI (Mouse Genome Informatics)

MGI:1306784
Synonyms ER154-like, Mrg1, Msg2, p35srj
Allele Name targeted mutation 1, Juan Pedro Martinez Barbera
Allele Symbol Cited2tm1Jpmb
MGI Allele Accession ID MGI:2176158
Mutant Construction Technique CRE recombinase-loxP technology
Phenotype
Phenotype Homozygous State Embryos die during gestation (~E15.5). Heart, left-right axis, neural tube, adrenal gland and placental defects.
Phenotype Heterozygous State None
Original Genetic Background 129P2/OlaHsd ES cells injected into C57BL/6 blastocysts
Genetic Background Currently Maintained C57BL/6
Coat Colour Black
Eye Colour Black
Strain identification
How is this strain characterised? Genotyping
Fertility and Strain maintenance
Fertility and Strain maintenance
Relevant bibliographic / database references
Strain Specific References
Other Related References
General information
Associated IP rights? No
Does it Model a Human Condition? Yes
Research value of this Strain Models human congenital malformations and placental insufficiency.
Applicable Research Areas Models for human disease
Cardiovascular
Developmental biology
Apoptosis
Keywords
  • Cited2
  • heart
  • placenta
  • left-right axis
Is the strain available in any form to other researchers Yes
APB stock stored as: Cryopreserved sperm (from 10 mice)
Are live mice available? Unknown
MTA needs to be signed? Yes


   

 


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