Mouse Strain information
APB ID 1636
Added 17/07/2007
Last Edited 11/05/2014
Strain name: B6.Cg-Tg(Lefty2-cre)21bHmd/Apb
Nickname: Lefty2-Cre ; L2Cre (Ninnag)
Strain designation name: B6.Cg-Tg(Lefty2-cre)21bHmd/Apb
Genetics
Strain Types Mutant strain
Congenic
Genetic Details Transgenic: CRE
Transgenic
Mode of Inheritance Dominant
1.   Transgene: transgene insertion 21b, Hiroshi Hamada  
Mutant Construction Technique CRE recombinase-loxP technology
Phenotype
Phenotype Homozygous State No overt phenotype
Phenotype Heterozygous State Expresses Cre-recombinase in mesoderm of 8.5dpc embryos. The promoter specifically directed cre expression in the epiblast and its derivatives between E5.5 and E8.0.
Original Genetic Background C2H;129;C57BL/6
Genetic Background Currently Maintained C57BL/6
Coat Colour Black
Eye Colour Black
Strain identification
How is this strain characterised? Genotyping
PCR protocols L2Cre (Ninnag)
Fertility and Strain maintenance
Fertility and Strain maintenance
Relevant bibliographic / database references
Strain Specific References
Other Related References
General information
Associated IP rights? No
Does it Model a Human Condition? Unknown
Applicable Research Areas Developmental biology
Cardiovascular
Keywords
  • Mesoderm
  • left-right
  • transcription
  • Nodal
Additional Information Strain was created in Hiroshi Hamada’s laboratory in Japan. Permission to freeze down but if another group wanted to bring up the line again he should be approached.
Is the strain available in any form to other researchers Yes
APB stock stored as: Cryopreserved sperm (from 10 mice)

APB stock genotyped verified by: The depositor
Are live mice available? Unknown
MTA needs to be signed? Yes


   

 


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