Mouse Strain information
APB ID 1626
Added 16/07/2007
Last Edited 11/05/2014
Strain name: 129X1;129S1-Cited2tm1.1Dunw/Apb
Nickname: C2X1f
Strain designation name: 129X1;129S1-Cited2tm1.1Dunw/Apb
Genetics
Strain Types Mutant strain
Genetic Details Targeted reporter
Targeted floxed
ES Cell-Line Used W9.5
Mode of Inheritance Recessive
1.  Affected Gene Name: Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2  
Chromosome 10
Affected Gene Symbol Cited2
Protein expression of altered gene: Normal
Genetic alteration of gene: The neomycin resistance cassette was removed from Cited2tm1Dunw, leaving exon 2 floxed and a lacZ downstream of the exon.
Location on chromosome (bp): 17443032-17444750 bp, + strand (From Ensembl annotation of NCBI Build 37)
MGI Gene Accession ID

Please also use this link to determine if other mutants have been registered with MGI (Mouse Genome Informatics)

MGI:1306784
Synonyms ER154-like, Mrg1, Msg2, p35srj
Allele Name targeted mutation 1.1, Sally L Dunwoodie
Allele Symbol Cited2tm1.1Dunw
MGI Allele Accession ID MGI:3696062
Mutant Construction Technique CRE recombinase-loxP technology
Candidate Gene Cited2
Phenotype
Phenotype Homozygous State Normal
Phenotype Heterozygous State None
Original Genetic Background 129S1/Sv-p+Tyr+KitlSl-J/+
Genetic Background Currently Maintained 129X1/SvJ
Coat Colour white to light chinchilla
Eye Colour red
Strain identification
How is this strain characterised? Genotyping
Fertility and Strain maintenance
Fertility and Strain maintenance
Relevant bibliographic / database references
Strain Specific References
Other Related References
General information
Associated IP rights? No
Does it Model a Human Condition? Yes
Research value of this Strain Strain models human congenital malformations and placental insufficiency.
Applicable Research Areas Models for human disease
Apoptosis
Developmental biology
Cardiovascular
Keywords
  • Cited2
  • heart
  • placenta
  • left-right axis
Additional Information Similar to C2f and C2Nf strains, however C2X1f does not contain neo compared to C2Nf strain and is on 129X1/SvJ background compared to C2f strain which is on mixed background
Is the strain available in any form to other researchers Yes
APB stock stored as: Cryopreserved sperm (from 15 mice)

APB stock genotyped verified by: The depositor
Are live mice available? Unknown
MTA needs to be signed? Yes


   

 


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