Mouse Strain information
APB ID 1524
Added 05/07/2007
Last Edited 11/05/2014
Strain name: C.Cg-Myd88tm1Aki Tg(CD2-IL5)5C2Ldt/Apb
Strain designation name: C.Cg-Myd88tm1Aki Tg(CD2-IL5)5C2Ldt/Apb
Genetics
Strain Types Mutant strain
Genetic Details Targeted knockout
Transgenic
Mode of Inheritance Recessive
1.  Affected Gene Name: myeloid differentiation primary response gene 88  
Chromosome 9
Affected Gene Symbol Myd88
Protein expression of altered gene: Nil
Genetic alteration of gene: A neomycin selection cassette replaced a 1.0 kb genomic fragment that contained sequences encoding the C-terminal cytoplasmic domain of the protein. Northern blot analysis confirmed that the encoded mRNA could not be detected in the liver and spleen of homozygous mice.
Location on chromosome (bp): 119245052-119250529 bp, - strand (From VEGA annotation of NCBI Build 37)
MGI Gene Accession ID

Please also use this link to determine if other mutants have been registered with MGI (Mouse Genome Informatics)

MGI:108005
Allele Name targeted mutation 1, Shizuo Akira
Allele Symbol Myd88tm1Aki
MGI Allele Accession ID MGI:2385681
Allele synonyms: MyD88 KO, MyD88-
1.   Transgene: transgene insertion 5C2, Lindsay A Dent  
Mutant Construction Technique None
Phenotype
Phenotype Homozygous State Provide a source of Myd88 deficient eosinophils
Original Genetic Background 129
Genetic Background Currently Maintained BALB/c
Strain identification
How is this strain characterised? Genotyping
Fertility and Strain maintenance
Fertility and Strain maintenance
Relevant bibliographic / database references
Strain Specific References
Other Related References
General information
Associated IP rights? No
Does it Model a Human Condition? Unknown
Applicable Research Areas Virology
Immunology and inflammation
Keywords
  • eosinophils
  • infection
  • virus clearance
  • TLR
  • interferon
Is the strain available in any form to other researchers Yes
APB stock stored as: Cryopreserved sperm (from 8 mice)

APB stock genotyped verified by: Unverified
Are live mice available? No
MTA needs to be signed? Yes


   

 


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