Mouse Strain information
APB ID 1521
Added 05/07/2007
Last Edited 11/05/2014
Strain name: C.129S1(B6)-Gata1tm6Sho/AnuApb
Strain designation name: C.129S1(B6)-Gata1tm6Sho/AnuApb
Genetics
Strain Types Mutant strain
Genetic Details Targeted knockout
Mode of Inheritance X-linked
1.  Affected Gene Name: GATA binding protein 1  
Chromosome X
Affected Gene Symbol Gata1
Protein expression of altered gene: Nil
Genetic alteration of gene: A high-affinity, palindromic "double" GATA protein binding site in the Gata1 promoter presumed to mediate positive Gata1 autoregulation was replaced by a floxed Pgk-neo cassette; transient Cre recombinase expression in ES cells left a single loxP site flanked by two Not1 sites. The 21-bp deleted segment comprised nucleotides -691 through -671 upstream of the last nucleotide of the first hematopoietically expressed exon of Gata1.
Location on chromosome (bp): 7536386-7555197 bp, - strand From VEGA annotation of NCBI Build 37)
MGI Gene Accession ID

Please also use this link to determine if other mutants have been registered with MGI (Mouse Genome Informatics)

MGI:95661
Synonyms Gata-1, Gf-1
Allele Name targeted mutation 6, Stuart Orkin
Allele Symbol Gata1tm6Sho
MGI Allele Accession ID MGI:3037864
Allele synonyms: deltadbl GATA, deltadblGATA, Gata1tm5Sho
Mutant Construction Technique None
Phenotype
Phenotype Homozygous State No eosinophils
Original Genetic Background 129S1/Sv
Genetic Background Currently Maintained BALB/c
Strain identification
How is this strain characterised? Genotyping
Fertility and Strain maintenance
Fertility and Strain maintenance
Relevant bibliographic / database references
Strain Specific References
Other Related References
General information
Associated IP rights? No
Does it Model a Human Condition? Unknown
Applicable Research Areas Haematology
Developmental biology
Immunology and inflammation
Keywords
  • eosinophil
  • promoter
  • inflammation
  • allergic
Is the strain available in any form to other researchers Yes
APB stock stored as: Cryopreserved sperm (from 10 mice)

APB stock genotyped verified by: Unverified
Are live mice available? No
MTA needs to be signed? Yes


   

 


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