Mouse Strain information
APB ID 138
Added 06/02/2006
Last Edited 11/05/2014
Strain name: C57BL/6JSfdAnu-Ptpn6me-v Tg(IghelMD4)4Ccg/AnuApb
Nickname: Mev:Hamlet
Strain designation name: C57BL/6JSfdAnu-Ptpn6me-v Tg(IghelMD4)4Ccg/AnuApb
Genetics
Strain Types Mutant strain
Coisogenic
Genetic Details Spontaneous
Transgenic
Mode of Inheritance Recessive
1.  Affected Gene Name: protein tyrosine phosphatase, non-receptor type 6  
Chromosome 6
Affected Gene Symbol Ptpn6
Protein expression of altered gene: Nil
Genetic alteration of gene: A T-to-A transversion point mutation at a splice consensus site results in the use of two other cryptic sites. One site would result in five amino acids being deleted from the encoded protein and the other would include 69bp of intronic sequence in the transcript
Location on chromosome (bp): 124670735-124683584 bp, - strand (From Ensembl annotation of NCBI Build 37)
MGI Gene Accession ID

Please also use this link to determine if other mutants have been registered with MGI (Mouse Genome Informatics)

MGI:96055
Synonyms hcp, Hcph, Ptp1C, SHP-1, Spin
Allele Name viable motheaten
Allele Symbol Ptpn6me-v
MGI Allele Accession ID MGI:1856074
1.   Transgene: transgene insertion 4, Christopher C Goodnow  
Mutant Construction Technique None
Phenotype
Original Genetic Background C57BL/6JSfd
Genetic Background Currently Maintained C57BL/6JSfdAnu
Strain identification
How is this strain characterised? Genotyping
PCR protocols Mev
Fertility and Strain maintenance
Fertility and Strain maintenance
Relevant bibliographic / database references
Strain Specific References
Other Related References
General information
Associated IP rights? No
Does it Model a Human Condition? No
Applicable Research Areas Cell biology
Developmental biology
Immunology and inflammation
Keywords
  • motheaten
  • phosphatase
  • SHP
  • B cell
  • lymphocyte
  • tyrosine kinase
  • signal transduction
Is the strain available in any form to other researchers Yes
APB stock stored as: Cryopreserved sperm (from 8 mice)

APB stock genotyped verified by: Unverified
Are live mice available? No
MTA needs to be signed? No


   

 


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