Mouse Strain information
APB ID 133
Added 06/02/2006
Last Edited 11/05/2014
Strain name: B10.Cg-H2k2 Tg(Dct-mHELKK)1Rc Tg(TcrHEL3A9)1Mmd/AnuApb
Nickname: Homer
Strain designation name: B10.Cg-H2k2 Tg(Dct-mHELKK)1Rc Tg(TcrHEL3A9)1Mmd/AnuApb
Genetics
Strain Types Mutant strain
Congenic
Genetic Details Transgenic
Mode of Inheritance Dominant
1.   Transgene: transgene insertion 1, Richard J Cornall  
2.   Transgene: transgene insertion 1, Mark M Davis  
1.  Affected Congenic Gene Name: histocompatibility-2, MHC  
Mutant Construction Technique None
Phenotype
Phenotype Homozygous State Mice develop a spontaneous autoimmune disease with striking similarity to human vitiligo vulgaris and Vogt-Koyanagi-Harada syndrome.
Original Genetic Background C57BL/6J
Genetic Background Currently Maintained C57BR
Strain identification
How is this strain characterised? Genotyping
Fertility and Strain maintenance
Fertility and Strain maintenance
Relevant bibliographic / database references
Strain Specific References
Other Related References
General information
Associated IP rights? No
Does it Model a Human Condition? Yes
Description of human condition: human vitiligo vulgaris and Vogt-Koyanagi-Harada syndrome
Research value of this Strain Offers model to test treatment for vitiligo
Applicable Research Areas Research tools
Dermatology
Immunology and inflammation
Keywords
  • CD4
  • T cell
  • vitiligo
  • melanocyte
  • autoimmunity
Is the strain available in any form to other researchers Yes
APB stock stored as: Cryopreserved sperm (from 8 mice)

APB stock genotyped verified by: Unverified
Are live mice available? No
MTA needs to be signed? Yes


   

 


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