Mouse Strain information
APB ID 112
Added 06/02/2006
Last Edited 02/05/2016
Strain name: C.B6-Klra8Cmv1-r H2b/AnuApb
Nickname: BALB/b-CMV1r
Strain designation name: C.B6-Klra8Cmv1-r H2b/AnuApb
Genetics
Strain Types Unclassified
Genetic Details Other mutation type
Mode of Inheritance Dominant
1.  Affected Gene Name: killer cell lectin-like receptor, subfamily A, member 8  
Chromosome 6
Affected Gene Symbol Klra8
Protein expression of altered gene: Normal
Location on chromosome (bp): 130065244-130079916 bp, - strand
MGI Gene Accession ID

Please also use this link to determine if other mutants have been registered with MGI (Mouse Genome Informatics)

MGI:102968
Synonyms Cmv-1, Cmv1, Ly49H, Ly49h, Ly49u129
Allele Name cytomegalovirus resistance 1, resistant
Allele Symbol Klra8Cmv1-r
MGI Allele Accession ID MGI:2387148
1.  Affected Congenic Gene Name: histocompatibility-2, MHC  
Mutant Construction Technique None
Phenotype
Phenotype Homozygous State The Klra8 gene from C57BL/6 has been recombined into the genome of Balb/c mice. The H2b locus of C57BL/6 has also been recombined into this BALB/c. Mice expressing Klra8 are resistant to CMV infection compared to BALB/c H2k2 and BALB/c H2b controls.
Original Genetic Background C57BL/6
Genetic Background Currently Maintained BALB/c
Coat Colour White
Eye Colour Red
Strain identification
How is this strain characterised? Genotyping
Fertility and Strain maintenance
Fertility and Strain maintenance
Relevant bibliographic / database references
Strain Specific References
Other Related References
General information
Associated IP rights? No
Does it Model a Human Condition? No
Applicable Research Areas Research tools
Immunology and inflammation
Keywords
  • cytomegalovirus
  • lymphocyte
  • natural killer cell
  • resistance
  • infection
Is the strain available in any form to other researchers Yes
APB stock stored as: Cryopreserved sperm (from 11 mice)

APB stock genotyped verified by: Unverified
Are live mice available? No
MTA needs to be signed? Yes


   

 


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