Mouse Strain information
APB ID 1
Added 25/11/2005
Last Edited 10/05/2014
Strain name: C57BL/6JSfdAnu-Ikzf1plstc/AnuApb
Nickname: Plastic
Strain designation name: C57BL/6JSfdAnu-Ikzf1plstc/AnuApb
Genetics
Strain Types Mutant strain
Genetic Details Chemically induced : ENU
Mode of Inheritance Recessive
1.  Affected Gene Name: IKAROS family zinc finger protein 1  
Chromosome 11
Affected Gene Symbol Ikzf1
Protein expression of altered gene: Nil
Genetic alteration of gene: ENU-induced mutation
Location on chromosome (bp): 11585006-11672115 bp, + strand (From VEGA annotation of NCBI Build 37)
MGI Gene Accession ID

Please also use this link to determine if other mutants have been registered with MGI (Mouse Genome Informatics)

MGI:1342540
Synonyms Ikaros, hlk-1, LyF-1, Zfpn1a1
Allele Name plastic
Allele Symbol Ikzf1plstc
MGI Allele Accession ID MGI:2669987
Ensembl Gene ID: ENSMUSG00000018654
Transcript ID: ENSMUST00000076700
Transcript name: Ikzf1-201
bp change: A to G at position 842 on cDNA
Exon number: 5
Exon ID: ENSMUSE00000655504
cDNA position: 842
Amino acid change: Histidine to Arginine at position 191
Sequence:
812CCTGCCGCCGGAGGGACGCCCTCACCGGCCACCTGAGGACGCACTCCGTTGGTAAGCCTCAcDNA (forward strand)
181A--C--R--R--R--D--A--L--T--G--H--L--R--T--H--S--V--G--K--P--Hprotein
Version: NCBI , Ensembl build 54
Mutant Construction Technique None
Phenotype
Phenotype Homozygous State Embryonic lethal E15.5-17.5 Anemia Failure of normal erythroblast growth and differentiation in fetal liver Expansion of myeloid cells including: CD34⁺CD45⁺FcγR⁺ and Mac-1hi and Gr-1lo cell populations No detectable Gr-1hi cells Early lymphocyte development arrest Accumulation of precursor B cells in thymus at expense of T cell development Premature down regulation of c-kit expression Cell intrinsic defect Fetal liver cells fail to engraft
Phenotype Heterozygous State T cell Lymphoma, arrested at DN (pro-T3) stage or Lymphoblastic lymphoma/leukaemia (pre-T-LBL)
Original Genetic Background C57BL/6JSfdAnu
Genetic Background Currently Maintained C57BL/6JSfdAnu
Strain Images
Affected animal
Affected animal
Strain identification
Fertility and Strain maintenance
Fertility and Strain maintenance
Relevant bibliographic / database references
Strain Specific References
Other Related References
General information
Associated IP rights? No
Does it Model a Human Condition? Unknown
Applicable Research Areas Internal/organ
Cancer
Immunology and inflammation
Keywords
  • haemopoiesis
  • T cell
  • B cell
  • transcription factor
  • ENU
Is the strain available in any form to other researchers Yes
APB stock stored as: Cryopreserved sperm (from 12 mice)
Are live mice available? No
MTA needs to be signed? Yes


   

 


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